Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053870258> ?p ?o ?g. }
- W2053870258 endingPage "1972" @default.
- W2053870258 startingPage "1964" @default.
- W2053870258 abstract "Erk5 is a recently discovered MAPK claimed to be responsible for some of the roles attributed to Erk1/2; here we report that it is activated in mitosis in comparison to G1/S. When Erk5 is inactivated pharmacologically or largely ablated by RNAi, cell survival in mitosis is diminished. We have previously shown Bim, a BH3-only protein of the Bcl-2 family, to be phosphorylated in mitosis, in a MEK-dependent manner (M. Grãos, A. D. Almeida, S. Chatterjee, Biochem. J. 388 (2005) 185). Inactivation of Erk5 in mitosis causes dephosphorylation of Bim. Bim is in the mitochondria in mitosis and when dephosphorylated interacts with Bax, inducing caspase activation. We also show that in mitosis Bim co-immunoprecipitates with Erk5 and Erk5 phosphorylates GST-Bim in in vitro kinase reaction. Taken together, our results identify a new target of the still largely mysterious Erk5 and suggest that Erk5 in mitosis may be a decisive step for the survival of proliferating cells." @default.
- W2053870258 created "2016-06-24" @default.
- W2053870258 creator A5027250861 @default.
- W2053870258 creator A5054921200 @default.
- W2053870258 creator A5072396493 @default.
- W2053870258 creator A5078363282 @default.
- W2053870258 date "2007-09-01" @default.
- W2053870258 modified "2023-10-12" @default.
- W2053870258 title "Erk5 is activated and acts as a survival factor in mitosis" @default.
- W2053870258 cites W1486549215 @default.
- W2053870258 cites W1536483289 @default.
- W2053870258 cites W1554372630 @default.
- W2053870258 cites W1593569677 @default.
- W2053870258 cites W1607777232 @default.
- W2053870258 cites W1662899239 @default.
- W2053870258 cites W1665993041 @default.
- W2053870258 cites W1774418672 @default.
- W2053870258 cites W1976720365 @default.
- W2053870258 cites W1981166298 @default.
- W2053870258 cites W1981303396 @default.
- W2053870258 cites W1991738330 @default.
- W2053870258 cites W1991972495 @default.
- W2053870258 cites W1996223704 @default.
- W2053870258 cites W2009279402 @default.
- W2053870258 cites W2009925333 @default.
- W2053870258 cites W2010968880 @default.
- W2053870258 cites W2013463734 @default.
- W2053870258 cites W2033968512 @default.
- W2053870258 cites W2035435624 @default.
- W2053870258 cites W2057163366 @default.
- W2053870258 cites W2061690334 @default.
- W2053870258 cites W2075757507 @default.
- W2053870258 cites W2080155235 @default.
- W2053870258 cites W2084107989 @default.
- W2053870258 cites W2094052642 @default.
- W2053870258 cites W2102827209 @default.
- W2053870258 cites W2102987835 @default.
- W2053870258 cites W2104933646 @default.
- W2053870258 cites W2108510669 @default.
- W2053870258 cites W2109838780 @default.
- W2053870258 cites W2110252008 @default.
- W2053870258 cites W2121796473 @default.
- W2053870258 cites W2123885531 @default.
- W2053870258 cites W2134416952 @default.
- W2053870258 cites W2134468110 @default.
- W2053870258 cites W2155380705 @default.
- W2053870258 cites W2165910529 @default.
- W2053870258 cites W2169253457 @default.
- W2053870258 cites W2170242482 @default.
- W2053870258 doi "https://doi.org/10.1016/j.cellsig.2007.05.005" @default.
- W2053870258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17624732" @default.
- W2053870258 hasPublicationYear "2007" @default.
- W2053870258 type Work @default.
- W2053870258 sameAs 2053870258 @default.
- W2053870258 citedByCount "36" @default.
- W2053870258 countsByYear W20538702582012 @default.
- W2053870258 countsByYear W20538702582013 @default.
- W2053870258 countsByYear W20538702582015 @default.
- W2053870258 countsByYear W20538702582016 @default.
- W2053870258 countsByYear W20538702582017 @default.
- W2053870258 countsByYear W20538702582018 @default.
- W2053870258 countsByYear W20538702582019 @default.
- W2053870258 countsByYear W20538702582020 @default.
- W2053870258 countsByYear W20538702582022 @default.
- W2053870258 countsByYear W20538702582023 @default.
- W2053870258 crossrefType "journal-article" @default.
- W2053870258 hasAuthorship W2053870258A5027250861 @default.
- W2053870258 hasAuthorship W2053870258A5054921200 @default.
- W2053870258 hasAuthorship W2053870258A5072396493 @default.
- W2053870258 hasAuthorship W2053870258A5078363282 @default.
- W2053870258 hasConcept C11960822 @default.
- W2053870258 hasConcept C178666793 @default.
- W2053870258 hasConcept C181912034 @default.
- W2053870258 hasConcept C184235292 @default.
- W2053870258 hasConcept C185592680 @default.
- W2053870258 hasConcept C190283241 @default.
- W2053870258 hasConcept C29537977 @default.
- W2053870258 hasConcept C502942594 @default.
- W2053870258 hasConcept C54355233 @default.
- W2053870258 hasConcept C86803240 @default.
- W2053870258 hasConcept C93304396 @default.
- W2053870258 hasConcept C95444343 @default.
- W2053870258 hasConceptScore W2053870258C11960822 @default.
- W2053870258 hasConceptScore W2053870258C178666793 @default.
- W2053870258 hasConceptScore W2053870258C181912034 @default.
- W2053870258 hasConceptScore W2053870258C184235292 @default.
- W2053870258 hasConceptScore W2053870258C185592680 @default.
- W2053870258 hasConceptScore W2053870258C190283241 @default.
- W2053870258 hasConceptScore W2053870258C29537977 @default.
- W2053870258 hasConceptScore W2053870258C502942594 @default.
- W2053870258 hasConceptScore W2053870258C54355233 @default.
- W2053870258 hasConceptScore W2053870258C86803240 @default.
- W2053870258 hasConceptScore W2053870258C93304396 @default.
- W2053870258 hasConceptScore W2053870258C95444343 @default.
- W2053870258 hasFunder F4320321868 @default.
- W2053870258 hasIssue "9" @default.
- W2053870258 hasLocation W20538702581 @default.
- W2053870258 hasLocation W20538702582 @default.