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- W2053871998 abstract "Abstract: We describe the clinical courses of 3 patients with hematologic malignancies (2 with acute myelogenous leukemia and 1 with multiple myeloma) who developed invasive fungal infections due to uncommon molds ( Alternaria spp., Paecilomyces lilacinus , and Zygomycetes). Breakthrough invasive fungal infections of the sinus ( n =1), lung ( n =3), and pericardium ( n =1) developed despite fluconazole prophylaxis and failed to respond to treatment with other licensed antifungal therapies, including amphotericin B ( n =3), caspofungin ( n =2), and voriconazole ( n =3), and surgical intervention ( n =2). Salvage therapy with posaconazole oral suspension resulted in successful outcomes in all 3 patients, who subsequently underwent allogeneic hematopoietic stem cell transplantation (HSCT) while on continued posaconazole therapy. The median duration of posaconazole treatment before HSCT was 5 months (range: 1.5–6 months). Posaconazole salvage therapy allowed successful allogeneic HSCT in 3 patients with refractory invasive mold infections." @default.
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- W2053871998 date "2007-04-25" @default.
- W2053871998 modified "2023-10-16" @default.
- W2053871998 title "Posaconazole salvage therapy allows successful allogeneic hematopoietic stem cell transplantation in patients with refractory invasive mold infections" @default.
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- W2053871998 doi "https://doi.org/10.1111/j.1399-3062.2007.00208.x" @default.
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