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• W2053876234 abstract "The nephrotoxicity of the aminoglycoside gentamicin was evaluated in anopen, controlled study of newborn infants randomly allocated to receive either combination drug therapy with gentamicin and ampicillin or single drug therapy with meziocillin for treatment of presumed neonatal sepsis. There were no significant differences in initial clinical characteristics between the groups. Neonates receiving gentamicin, in contrast to those receiving meziocillin, had significant nephrotoxicity manifested by a smaller postnatal fall in mean serum creatinine concentration (−9%, P NS vs −21%, P<0.005, respectively) and a diminished postnatal rise in mean creatinine clearance (+21%, P NS vs+51%, P <0.01, respectively). In neonates with a fall in creatinine clearance, the mean decline was significantly greater in those receiving gentamicin (44% vs 20%, P <0.01). There was no relationship between the incidence of gentamicin nephrotoxicity and either peak or trough gentamicin levels. For treatment of presumed neonatal sepsis, gentamicin proved more nephrotoxic than meziocillin. The nephrotoxicity of the aminoglycoside gentamicin was evaluated in anopen, controlled study of newborn infants randomly allocated to receive either combination drug therapy with gentamicin and ampicillin or single drug therapy with meziocillin for treatment of presumed neonatal sepsis. There were no significant differences in initial clinical characteristics between the groups. Neonates receiving gentamicin, in contrast to those receiving meziocillin, had significant nephrotoxicity manifested by a smaller postnatal fall in mean serum creatinine concentration (−9%, P NS vs −21%, P<0.005, respectively) and a diminished postnatal rise in mean creatinine clearance (+21%, P NS vs+51%, P <0.01, respectively). In neonates with a fall in creatinine clearance, the mean decline was significantly greater in those receiving gentamicin (44% vs 20%, P <0.01). There was no relationship between the incidence of gentamicin nephrotoxicity and either peak or trough gentamicin levels. For treatment of presumed neonatal sepsis, gentamicin proved more nephrotoxic than meziocillin." @default.
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• W2053876234 date "1987-12-01" @default.
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• W2053876234 title "A controlled study of the nephrotoxicity of mezlocillin and gentamicin plus ampicillin in the neonate" @default.
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• W2053876234 doi "https://doi.org/10.1016/s0022-3476(87)80212-3" @default.
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