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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053876753> ?p ?o ?g. }

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• W2053876753 abstract "A series of novel dopamine D1 antagonists derived from functionalization of the D-ring of SCH 39166 were prepared. A number of these compounds displayed subnanomolar D1 activity and more than 1000-fold selectivity over D2. We found C-3 derivatization afforded compounds with superior overall profile in comparison to the C-2 and C-4 derivatization. A number of highly potent D1 antagonists were discovered which have excellent selectivity over other dopamine receptors and improved PK profile compared to SCH 39166." @default.
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• W2053876753 date "2010-02-01" @default.
• W2053876753 modified "2023-09-23" @default.
• W2053876753 title "Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists" @default.
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• W2053876753 doi "https://doi.org/10.1016/j.bmcl.2009.12.100" @default.
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