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• W2053877251 abstract "Abstract Corticosteroid use after transplantation is associated with an increased incidence of cardiovascular events and death. Cerebrovascular disease is a common cause of morbidity and mortality post‐renal transplantation; however, a dedicated analysis of cerebrovascular disease in recipients of a steroid sparing protocol has not been reported. The aim of this study was to examine the incidence, risk factors, and outcomes of CVA in transplant recipients receiving a steroid sparing protocol. We retrospectively analyzed 1237 patients who received a kidney alone or a simultaneous pancreas and kidney ( SPK ) transplant. Fifty‐six of 1237 (4.53%) patients had a CVA post‐transplant. All‐cause mortality was significantly higher in the CVA group compared with the non‐ CVA group, OR : 3.4 (1.7–7.0), p < 0.001. Factors found to be associated with increased risk of CVA by multivariate analysis were older age, HR : 1.07 (1.04–1.09), p < 0.001; diabetes at the time of transplantation, HR : 2.83 (1.42–5.64), p = 0.003; corticosteroid use pre‐transplant, HR : 3.27 (1.29–8.27), p = 0.013 and recipients of a SPK , HR : 4.03 (1.85–8.79), p < 0.001. This study has identified subgroups of patients who are at increased risk of CVA post‐transplant in patients otherwise receiving a steroid sparing immunosuppression protocol." @default.
• W2053877251 created "2016-06-24" @default.
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• W2053877251 date "2014-11-19" @default.
• W2053877251 modified "2023-10-18" @default.
• W2053877251 title "Incidence, risk factors, and outcomes of stroke post‐transplantation in patients receiving a steroid sparing immunosuppression protocol" @default.
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• W2053877251 doi "https://doi.org/10.1111/ctr.12476" @default.
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