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- W2053878748 abstract "Several subunit vaccine antigens have been successfully expressed in plants and recently the hepatitis B surface antigen (HBsAg), expressed in potatoes, was shown to be orally immunogenic in animal studies. However, to date, a detailed analysis of the plant-derived antigen is lacking. Herein, we comprehensively characterize the structure and post-translational processing of HBsAg from potato tuber and two plant cell suspension cultures. The HBsAg was found to accumulate intracellularly as tubular structures, with a complex size distribution, differing substantially from the virus-like particle (VLP) preparations of the current commercial vaccines. Extensive disulfide-bond cross-linking, which is important for immunogenicity, was evident and 21-37% of total HBsAg protein displayed epitopes which correlate with vaccine potency. The significance of these results with regard to the production of cost-effective orally delivered vaccines is discussed." @default.
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- W2053878748 date "2003-09-01" @default.
- W2053878748 modified "2023-10-17" @default.
- W2053878748 title "Structural characterization of plant-derived hepatitis B surface antigen employed in oral immunization studies" @default.
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- W2053878748 doi "https://doi.org/10.1016/s0264-410x(03)00268-8" @default.
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