FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053886237> ?p ?o ?g. }

• W2053886237 endingPage "41" @default.
• W2053886237 startingPage "34" @default.
• W2053886237 abstract "The overall picture as regards cellular mechanisms in immunologic tolerance is thus clear. Thymic negative selection is an important and dominant mechanism for both CD4+ and CD8+ T cells for those antigens (and they may be very many indeed), the peptides of which get expressed within the thymus. The induction of anergy among peripheral T lymphocytes may represent an ancillary mechanism in some cases, but this is not as clear as it appeared 2 or 3 years ago. Evidently, in many cases, T cells simply ignore antigens present only within specialized organs, and these T cells, even if only of low affinity for the antigen in question, could be provoked into autoimmunity if sufficient help is provided, for example, through localized production of IL-2 or through provision of cross-reactive help. B-cell tolerance is also proven and involves deletional mechanisms (most likely maturation arrest) or functional inactivation (clonal anergy). The former phenomenon dominates for self-antigens that strongly cross-link the B cell's Ig receptors and the latter for weaker negative signals. Despite these two mechanisms, clonal ignorance prevails for many self-antigens. The secondary B-cell repertoire is also largely free of anti-self B cells, lack of T-cell help being a major factor in preventing the development of anti-self memory B cells. Therefore, to have the best chance of creating an immunogenic antitumor vaccine, a few simple and rather obvious rules must be followed. The antigen in question must be presented in such a way as to be palatable to professional antigen-presenting cells, particularly dendritic cells and macrophages. Immunotherapy protocols should avoid at all costs the widespread distribution of the antigen in question through the extracellular fluids. Indeed, it is possible that widespread circulation of a tumor-associated antigen through the serum and lymph because of large-scale shedding from the tumor cell may already have created a substantial degree of tolerance to the antigen in question in both T- and B-cell populations. If that has happened, it becomes particularly important to create a cancer vaccine capable of inducing help. This may well involve coupling of the most important epitopes to some highly immunogenic and foreign carrier. A wide choice of adjuvants is available for the designer of tumor vaccines, and in this regard the cancer immunotherapy community has much to learn from the rapidly developing field of infectious disease vaccinology using recombinant and other vaccines.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2053886237 created "2016-06-24" @default.
• W2053886237 creator A5017796409 @default.
• W2053886237 date "1993-08-01" @default.
• W2053886237 modified "2023-09-23" @default.
• W2053886237 title "Tolerance and Ways to Break It" @default.
• W2053886237 cites W1576195593 @default.
• W2053886237 cites W1676768529 @default.
• W2053886237 cites W1963754382 @default.
• W2053886237 cites W1966949480 @default.
• W2053886237 cites W1972354503 @default.
• W2053886237 cites W1976046500 @default.
• W2053886237 cites W1986356667 @default.
• W2053886237 cites W1988374284 @default.
• W2053886237 cites W1996025437 @default.
• W2053886237 cites W2015994130 @default.
• W2053886237 cites W2016208323 @default.
• W2053886237 cites W2024276432 @default.
• W2053886237 cites W2026891958 @default.
• W2053886237 cites W2046749316 @default.
• W2053886237 cites W2049914202 @default.
• W2053886237 cites W2050774038 @default.
• W2053886237 cites W2052458695 @default.
• W2053886237 cites W2070143807 @default.
• W2053886237 cites W2077027589 @default.
• W2053886237 cites W2078702573 @default.
• W2053886237 cites W2086214520 @default.
• W2053886237 cites W2088070169 @default.
• W2053886237 cites W2095330021 @default.
• W2053886237 cites W2125504851 @default.
• W2053886237 cites W2173328322 @default.
• W2053886237 cites W2180896468 @default.
• W2053886237 cites W2788704958 @default.
• W2053886237 doi "https://doi.org/10.1111/j.1749-6632.1993.tb43993.x" @default.
• W2053886237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8368749" @default.
• W2053886237 hasPublicationYear "1993" @default.
• W2053886237 type Work @default.
• W2053886237 sameAs 2053886237 @default.
• W2053886237 citedByCount "39" @default.
• W2053886237 countsByYear W20538862372012 @default.
• W2053886237 countsByYear W20538862372013 @default.
• W2053886237 countsByYear W20538862372017 @default.
• W2053886237 countsByYear W20538862372022 @default.
• W2053886237 crossrefType "journal-article" @default.
• W2053886237 hasAuthorship W2053886237A5017796409 @default.
• W2053886237 hasConcept C121332964 @default.
• W2053886237 hasConcept C147483822 @default.
• W2053886237 hasConcept C159654299 @default.
• W2053886237 hasConcept C19317047 @default.
• W2053886237 hasConcept C203014093 @default.
• W2053886237 hasConcept C24890656 @default.
• W2053886237 hasConcept C2776090121 @default.
• W2053886237 hasConcept C2777016536 @default.
• W2053886237 hasConcept C2777702733 @default.
• W2053886237 hasConcept C2777868816 @default.
• W2053886237 hasConcept C2778453870 @default.
• W2053886237 hasConcept C2778473898 @default.
• W2053886237 hasConcept C2779062720 @default.
• W2053886237 hasConcept C2780130043 @default.
• W2053886237 hasConcept C2909320318 @default.
• W2053886237 hasConcept C86803240 @default.
• W2053886237 hasConcept C8891405 @default.
• W2053886237 hasConcept C95444343 @default.
• W2053886237 hasConceptScore W2053886237C121332964 @default.
• W2053886237 hasConceptScore W2053886237C147483822 @default.
• W2053886237 hasConceptScore W2053886237C159654299 @default.
• W2053886237 hasConceptScore W2053886237C19317047 @default.
• W2053886237 hasConceptScore W2053886237C203014093 @default.
• W2053886237 hasConceptScore W2053886237C24890656 @default.
• W2053886237 hasConceptScore W2053886237C2776090121 @default.
• W2053886237 hasConceptScore W2053886237C2777016536 @default.
• W2053886237 hasConceptScore W2053886237C2777702733 @default.
• W2053886237 hasConceptScore W2053886237C2777868816 @default.
• W2053886237 hasConceptScore W2053886237C2778453870 @default.
• W2053886237 hasConceptScore W2053886237C2778473898 @default.
• W2053886237 hasConceptScore W2053886237C2779062720 @default.
• W2053886237 hasConceptScore W2053886237C2780130043 @default.
• W2053886237 hasConceptScore W2053886237C2909320318 @default.
• W2053886237 hasConceptScore W2053886237C86803240 @default.
• W2053886237 hasConceptScore W2053886237C8891405 @default.
• W2053886237 hasConceptScore W2053886237C95444343 @default.
• W2053886237 hasIssue "1" @default.
• W2053886237 hasLocation W20538862371 @default.
• W2053886237 hasLocation W20538862372 @default.
• W2053886237 hasOpenAccess W2053886237 @default.
• W2053886237 hasPrimaryLocation W20538862371 @default.
• W2053886237 hasRelatedWork W13373385 @default.
• W2053886237 hasRelatedWork W184563565 @default.
• W2053886237 hasRelatedWork W1979086447 @default.
• W2053886237 hasRelatedWork W2063666690 @default.
• W2053886237 hasRelatedWork W2098431383 @default.
• W2053886237 hasRelatedWork W2115134592 @default.
• W2053886237 hasRelatedWork W2117570533 @default.
• W2053886237 hasRelatedWork W2157186145 @default.
• W2053886237 hasRelatedWork W2157656889 @default.
• W2053886237 hasRelatedWork W2402113949 @default.
• W2053886237 hasVolume "690" @default.
• W2053886237 isParatext "false" @default.

• next