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• W2053886270 abstract "The evolution from microarrays to transcriptome deep-sequencing (RNA-seq) and from RNA interference to gene knockouts using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and Transcription Activator-Like Effector Nucleases (TALENs) has provided a new experimental partnership for identifying and quantifying the effects of gene changes on drug resistance. Here we describe the results from deep-sequencing of RNA derived from two cytarabine (Ara-C) resistance acute myeloid leukemia (AML) cell lines and present CRISPR and TALEN based methods for accomplishing complete gene knockout (KO) in AML cells. We found protein modifying loss-of-function mutations in Dck in both Ara-C resistant cell lines. CRISPR and TALEN-based KO of Dck dramatically increased the IC50 of Ara-C and introduction of a DCK overexpression vector into Dck KO clones resulted in a significant increase in Ara-C sensitivity. This effort demonstrates the power of using transcriptome analysis and CRISPR/TALEN-based KOs to identify and verify genes associated with drug resistance." @default.
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• W2053886270 date "2014-08-13" @default.
• W2053886270 modified "2023-10-10" @default.
• W2053886270 title "Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia" @default.
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• W2053886270 doi "https://doi.org/10.1038/srep06048" @default.
• W2053886270 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4131221" @default.
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