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- W2053887196 abstract "Many round, pale yellow, cytoplasmic inclusion bodies were found in hematoxylin and eosin-stained sections of a hyalinizing trabecular adenoma of the thyroid. The bodies were refractile and frequently had a microvacuolated or granular substructure. They were usually located close to the nucleus, often indented it, and rarely occurred within it. Histochemically, they showed a glycosaminoglycan, proteoglycan, and lipid content, displayed autofluorescence on exposure to ultraviolet light, and were unreactive with a variety of immunostains. Ultrastructurally, the inclusions were consistent with giant lysosomes, showing parallel whorled and arrayed membranes (fingerprint bodies) as a component of their substructure. Review of sections of 75 hyalinizing trabecular adenomas in our files revealed that the cytoplasmic bodies were present in all cases (100%), indicating that these inclusions most likely are a universal feature of the neoplasm." @default.
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- W2053887196 date "1999-01-01" @default.
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- W2053887196 title "Hyalinizing Trabecular Adenoma of the Thyroid Gland" @default.
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- W2053887196 doi "https://doi.org/10.1097/00000478-199901000-00014" @default.
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