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• W2053887995 startingPage "125" @default.
• W2053887995 abstract "Tricyclohexylhydroxytin, commonly known as Plictran, inhibited Na+, K+-ATPase activity of rat brain synaptosomes in a concentration-dependent manner with median inhibitory concentration (IC-50) of 2 microM. Both K+-stimulated para-nitrophenylphosphatase and [3-H]-ouabain binding to synaptosomes were also inhibited by Plictran with IC-50 values of 11 and 30 microM, respectively. Altered pH and Na+, K+-ATPase activity curves demonstrated comparable inhibition in buffered neutral and alkaline pH ranges, and no inhibition was observed in acidic pH. The inhibition of Na+, K+-ATPase was independent of temperature. Kinetic studies of substrate (ATP) activation of Na+, K+-ATPase indicated uncompetitive inhibition. Results also showed noncompetitive inhibition for p-nitrophenylphosphate and uncompetitive inhibition for K+ activations of p-nitrophenylphosphatase. Preincubation of synaptosomes with dithiothreitol, a sulfhydryl (SH) agent, resulted in the complete protection of Plictran inhibition of Na+, K+-ATPase, K+-para-nitrophenylphosphatase, and [3-H]-ouabain binding. The protection was specific and concentration dependent since cysteine and glutathione did not afford protection. These results indicate that Plictran inhibited Na+, K+-ATPase by interacting with dephosphorylation of the enzyme-phosphoryl complex and exerted a similar effect to that of SH-blocking agents." @default.
• W2053887995 created "2016-06-24" @default.
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• W2053887995 creator A5057903147 @default.
• W2053887995 date "1987-01-01" @default.
• W2053887995 modified "2023-10-13" @default.
• W2053887995 title "Effects of tricyclohexylhydroxytin on the kinetics of adenosine triphosphatase system and protection by thiol reagents" @default.
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• W2053887995 doi "https://doi.org/10.1002/jbt.2570020206" @default.
• W2053887995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2854565" @default.
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