Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053897163> ?p ?o ?g. }
- W2053897163 abstract "Background—Certain bone marrow-derived cell populations, termed endothelial progenitor cells (EPCs), have been reported to possess angiogenic activity. Experimental data suggest that depletion of these angiogenic cell populations may promote atherogenesis, but limited data are available regarding their relation to subclinical atherosclerotic cardiovascular disease in humans. Correspondence: Thomas J. Wang, MD, Cardiology Division, GRB-800, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114; Phone (617) 724-6158; Fax (617) 726-4105; tjwang@partners.org. *Authors provided equal contribution Conflicts of Interest / Disclosures None. NIH Public Access Author Manuscript Circulation. Author manuscript; available in PMC 2011 September 21. Published in final edited form as: Circulation. 2010 September 21; 122(12): 1176–1182. doi:10.1161/CIRCULATIONAHA.109.931279. N IH PA Athor M anscript N IH PA Athor M anscript N IH PA Athor M anscript Methods and Results—We studied 889 participants of the Framingham Heart Study who were free of clinically apparent cardiovascular disease (mean age, 65 years; 55% women). Participants underwent EPC phenotyping using an early outgrowth colony forming unit (CFU) assay and cell surface markers. Participants also underwent non-contrast multidetector computed tomography to assess the presence of subclinical atherosclerosis, as reflected by burden of coronary artery calcification (CAC) and abdominal aortic calcification (AAC). In this study sample, we examined the association of EPC-related phenotypes with both CAC and AAC. Across decreasing tertiles of CFU, there was a progressive increase in median CAC and AAC scores. In multivariable analyses adjusting for traditional cardiovascular risk factors, each standard deviation increase in CFU was associated with an approximately 16% decrease in CAC (P=0.02) and 17% decrease in AAC (P=0.03). In contrast, neither CD34+/KDR+ nor CD34+ variation were associated with significant differences in coronary or aortic calcification. Conclusion—In this large, community-based sample of men and women, lower CFU number was associated with a higher burden of subclinical atherosclerosis in the coronary arteries and aorta. Decreased angiogenic potential could contribute to the development of atherosclerosis in humans." @default.
- W2053897163 created "2016-06-24" @default.
- W2053897163 creator A5024042478 @default.
- W2053897163 creator A5025658340 @default.
- W2053897163 creator A5065574984 @default.
- W2053897163 date "2011-01-01" @default.
- W2053897163 modified "2023-09-28" @default.
- W2053897163 title "Association of Colony-Forming Units With Coronary Artery and Abdominal Aortic Calcification" @default.
- W2053897163 cites W1569560733 @default.
- W2053897163 cites W1900792919 @default.
- W2053897163 cites W1969678022 @default.
- W2053897163 cites W1974273913 @default.
- W2053897163 cites W1974812650 @default.
- W2053897163 cites W1975565584 @default.
- W2053897163 cites W1976291192 @default.
- W2053897163 cites W1979485167 @default.
- W2053897163 cites W1982651263 @default.
- W2053897163 cites W1983541079 @default.
- W2053897163 cites W1983979356 @default.
- W2053897163 cites W1990182032 @default.
- W2053897163 cites W1993524880 @default.
- W2053897163 cites W2008062232 @default.
- W2053897163 cites W2016671253 @default.
- W2053897163 cites W2025666964 @default.
- W2053897163 cites W2027866013 @default.
- W2053897163 cites W2031684831 @default.
- W2053897163 cites W2034924908 @default.
- W2053897163 cites W2036057897 @default.
- W2053897163 cites W2042116568 @default.
- W2053897163 cites W2043713711 @default.
- W2053897163 cites W2047571038 @default.
- W2053897163 cites W2051734973 @default.
- W2053897163 cites W2061566600 @default.
- W2053897163 cites W2083384274 @default.
- W2053897163 cites W2091674433 @default.
- W2053897163 cites W2095022753 @default.
- W2053897163 cites W2105766576 @default.
- W2053897163 cites W2115564331 @default.
- W2053897163 cites W2127872440 @default.
- W2053897163 cites W2128798348 @default.
- W2053897163 cites W2130761693 @default.
- W2053897163 cites W2132418620 @default.
- W2053897163 cites W2140944993 @default.
- W2053897163 cites W2144755498 @default.
- W2053897163 cites W2145653003 @default.
- W2053897163 cites W2147513525 @default.
- W2053897163 cites W2149860264 @default.
- W2053897163 cites W2150762378 @default.
- W2053897163 cites W2152854915 @default.
- W2053897163 cites W2153785016 @default.
- W2053897163 cites W2163749156 @default.
- W2053897163 cites W2168282871 @default.
- W2053897163 cites W2211287272 @default.
- W2053897163 doi "https://doi.org/10.1016/j.jvs.2010.11.039" @default.
- W2053897163 hasPublicationYear "2011" @default.
- W2053897163 type Work @default.
- W2053897163 sameAs 2053897163 @default.
- W2053897163 citedByCount "0" @default.
- W2053897163 crossrefType "journal-article" @default.
- W2053897163 hasAuthorship W2053897163A5024042478 @default.
- W2053897163 hasAuthorship W2053897163A5025658340 @default.
- W2053897163 hasAuthorship W2053897163A5065574984 @default.
- W2053897163 hasBestOaLocation W20538971631 @default.
- W2053897163 hasConcept C113280763 @default.
- W2053897163 hasConcept C126322002 @default.
- W2053897163 hasConcept C164705383 @default.
- W2053897163 hasConcept C201750760 @default.
- W2053897163 hasConcept C2778213512 @default.
- W2053897163 hasConcept C2780152582 @default.
- W2053897163 hasConcept C2780309369 @default.
- W2053897163 hasConcept C28328180 @default.
- W2053897163 hasConcept C2991716557 @default.
- W2053897163 hasConcept C54355233 @default.
- W2053897163 hasConcept C71924100 @default.
- W2053897163 hasConcept C86803240 @default.
- W2053897163 hasConceptScore W2053897163C113280763 @default.
- W2053897163 hasConceptScore W2053897163C126322002 @default.
- W2053897163 hasConceptScore W2053897163C164705383 @default.
- W2053897163 hasConceptScore W2053897163C201750760 @default.
- W2053897163 hasConceptScore W2053897163C2778213512 @default.
- W2053897163 hasConceptScore W2053897163C2780152582 @default.
- W2053897163 hasConceptScore W2053897163C2780309369 @default.
- W2053897163 hasConceptScore W2053897163C28328180 @default.
- W2053897163 hasConceptScore W2053897163C2991716557 @default.
- W2053897163 hasConceptScore W2053897163C54355233 @default.
- W2053897163 hasConceptScore W2053897163C71924100 @default.
- W2053897163 hasConceptScore W2053897163C86803240 @default.
- W2053897163 hasLocation W20538971631 @default.
- W2053897163 hasOpenAccess W2053897163 @default.
- W2053897163 hasPrimaryLocation W20538971631 @default.
- W2053897163 hasRelatedWork W1992858836 @default.
- W2053897163 hasRelatedWork W2006175205 @default.
- W2053897163 hasRelatedWork W2018888084 @default.
- W2053897163 hasRelatedWork W2043713711 @default.
- W2053897163 hasRelatedWork W2074015963 @default.
- W2053897163 hasRelatedWork W2085236732 @default.
- W2053897163 hasRelatedWork W2088807230 @default.
- W2053897163 hasRelatedWork W2091441230 @default.
- W2053897163 hasRelatedWork W2096794438 @default.
- W2053897163 hasRelatedWork W2100204688 @default.