Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053906877> ?p ?o ?g. }
- W2053906877 endingPage "302" @default.
- W2053906877 startingPage "294" @default.
- W2053906877 abstract "During the last step of alphabeta T cell development, thymocytes that have rearranged genes encoding TCR chains and express CD4 and CD8 coreceptors are selected on the basis of their TCR reactivity to escape programmed cell death and become mature CD4 or CD8 T cells. This process is triggered by intrathymic TCR signaling, that activates 'sensor' transcription factors 'constitutively' expressed in DP thymocytes. Eventually, TCR-signaled thymocytes evolve effector transcriptional circuits that control basal metabolism, migration, survival and initiation of lineage-specific gene expression. This review examines how components of the 'sensing' transcription apparatus responds to positive selection signals, and highlights important differences with mature T cell responses. In a second part, we evaluate current observations and hypotheses on the connections between sensing transcription factors and effector circuitries." @default.
- W2053906877 created "2016-06-24" @default.
- W2053906877 creator A5024838548 @default.
- W2053906877 creator A5042053176 @default.
- W2053906877 creator A5071263465 @default.
- W2053906877 date "2010-10-01" @default.
- W2053906877 modified "2023-10-16" @default.
- W2053906877 title "Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection" @default.
- W2053906877 cites W1491270159 @default.
- W2053906877 cites W1503471785 @default.
- W2053906877 cites W1504215273 @default.
- W2053906877 cites W1522775746 @default.
- W2053906877 cites W1529305202 @default.
- W2053906877 cites W1530165617 @default.
- W2053906877 cites W1530926870 @default.
- W2053906877 cites W1554464948 @default.
- W2053906877 cites W1565044685 @default.
- W2053906877 cites W1569503463 @default.
- W2053906877 cites W1581327117 @default.
- W2053906877 cites W1581345953 @default.
- W2053906877 cites W1587787638 @default.
- W2053906877 cites W1601504908 @default.
- W2053906877 cites W1606273823 @default.
- W2053906877 cites W1673471110 @default.
- W2053906877 cites W1682246834 @default.
- W2053906877 cites W1773386990 @default.
- W2053906877 cites W1834788462 @default.
- W2053906877 cites W1847275787 @default.
- W2053906877 cites W1885758189 @default.
- W2053906877 cites W1893260165 @default.
- W2053906877 cites W1900623676 @default.
- W2053906877 cites W1945715178 @default.
- W2053906877 cites W1964581938 @default.
- W2053906877 cites W1966664168 @default.
- W2053906877 cites W1966828006 @default.
- W2053906877 cites W1967973978 @default.
- W2053906877 cites W1968771968 @default.
- W2053906877 cites W1969589172 @default.
- W2053906877 cites W1976457453 @default.
- W2053906877 cites W1976505472 @default.
- W2053906877 cites W1978972286 @default.
- W2053906877 cites W1979067200 @default.
- W2053906877 cites W1980926721 @default.
- W2053906877 cites W1982581668 @default.
- W2053906877 cites W1982956925 @default.
- W2053906877 cites W1983249949 @default.
- W2053906877 cites W1985615861 @default.
- W2053906877 cites W1986922495 @default.
- W2053906877 cites W1987684167 @default.
- W2053906877 cites W1989316550 @default.
- W2053906877 cites W1989875191 @default.
- W2053906877 cites W1992031335 @default.
- W2053906877 cites W1992572858 @default.
- W2053906877 cites W1992873829 @default.
- W2053906877 cites W1994782667 @default.
- W2053906877 cites W1995205975 @default.
- W2053906877 cites W1995421851 @default.
- W2053906877 cites W1995540562 @default.
- W2053906877 cites W1996713852 @default.
- W2053906877 cites W1998000578 @default.
- W2053906877 cites W1999341695 @default.
- W2053906877 cites W2000912815 @default.
- W2053906877 cites W2002301651 @default.
- W2053906877 cites W2005273809 @default.
- W2053906877 cites W2007662459 @default.
- W2053906877 cites W2008403890 @default.
- W2053906877 cites W2009116858 @default.
- W2053906877 cites W2009229814 @default.
- W2053906877 cites W2009938527 @default.
- W2053906877 cites W2012790485 @default.
- W2053906877 cites W2015756553 @default.
- W2053906877 cites W2020713861 @default.
- W2053906877 cites W2020955202 @default.
- W2053906877 cites W2023601085 @default.
- W2053906877 cites W2024036298 @default.
- W2053906877 cites W2025567420 @default.
- W2053906877 cites W2029031393 @default.
- W2053906877 cites W2030410762 @default.
- W2053906877 cites W2032406291 @default.
- W2053906877 cites W2033360952 @default.
- W2053906877 cites W2036455976 @default.
- W2053906877 cites W2036498443 @default.
- W2053906877 cites W2037264586 @default.
- W2053906877 cites W2037553038 @default.
- W2053906877 cites W2038469447 @default.
- W2053906877 cites W2039953294 @default.
- W2053906877 cites W2044886875 @default.
- W2053906877 cites W2051349356 @default.
- W2053906877 cites W2053414430 @default.
- W2053906877 cites W2054969526 @default.
- W2053906877 cites W2056597149 @default.
- W2053906877 cites W2057781689 @default.
- W2053906877 cites W2058288999 @default.
- W2053906877 cites W2060177226 @default.
- W2053906877 cites W2061519511 @default.
- W2053906877 cites W2064018023 @default.
- W2053906877 cites W2064553744 @default.
- W2053906877 cites W2065755680 @default.