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• W2053913358 abstract "Functions and regulation of selected human UDP-glucuronosyltransferases (UGT1A1, UGT1A4, UGT1A6, UGT1A9, UGT2B7, UGT2B15) are summarized. Evidence for at least two PAH-inducible UGTs (UGT1A6 and UGT1A9) is presented, which, however, are also constitutively expressed in a tissue- and cell-specific manner. These isoforms have recently been characterized to conjugate planar and bulky phenols, respectively. Using a selective RT-PCR method, UGT1A6 expression was detected in a variety of tissues (liver, kidney, lung, intestine, and pharyngeal mucosa). PAH-inducible UGTs may cooperate in the metabolism of phenolic metabolites of benzo(a)pyrene. Studies with stably expressed isoforms suggest that UGT1A9 is responsible for the formation of benzo(a)pyrene-3.6-diphenol diglucuronide, the major biliary metabolite of benzo(a)pyrene." @default.
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• W2053913358 date "1999-01-01" @default.
• W2053913358 modified "2023-09-23" @default.
• W2053913358 title "FUNCTIONS AND TRANSCRIPTIONAL REGULATION OF PAH-INDUCIBLE HUMAN UDP-GLUCURONOSYL-TRANSFERASES" @default.
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• W2053913358 doi "https://doi.org/10.1081/dmr-100101927" @default.
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