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- W2053978455 abstract "Background: Despite advances in therapy for acute myocardial infarction, mortality and morbidity related to post–myocardial infarction (MI) left ventricular dysfunction remain high. To date, the clinical tools for preventing post-MI heart failure have been limited to rapid reperfusion and postinfarction drug therapy. Recently, there has also been considerable interest in novel approaches aimed at preventing reperfusion injury and improving infarct healing, including stem cell therapy. Several preclinical studies and small clinical trials have demonstrated the potential benefit of bone marrow–derived cell-based therapies in the treatment of post-MI left ventricular dysfunction. These studies have focused on the whole mononuclear cell fraction of bone marrow, because it is unclear which cell type or combination of cell types may be responsible for the promising early results. The REPAIR-AMI trial was the largest, randomized, double-blind, placebo-controlled study to evaluate the effects of intracoronary delivery of progenitor cells after primary percutaneous coronary intervention (PCI) for ST-segment elevation MI. The study involved 204 patients at 17 medical centers in Germany and Switzerland. After bone marrow aspiration, patients" @default.
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- W2053978455 date "2006-02-01" @default.
- W2053978455 modified "2023-10-17" @default.
- W2053978455 title "Highlights from the American Heart Association Scientific Sessions, November 13 to 16, 2005, Dallas, TX" @default.
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- W2053978455 doi "https://doi.org/10.1016/j.ahj.2005.12.011" @default.
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