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• W2053982423 startingPage "716" @default.
• W2053982423 abstract "The ecdysone receptor is a heterodimer of the two nuclear receptors EcR and ultraspiracle (USP). We have identified the regions of Drosophila EcR and USP responsible for transcriptional activation of a semisynthetic Eip71CD promoter in Kc cells. The isoform-specific A/B domains of EcR-B1 and B2, but not those of EcR-A or USP, exhibit strong activation activity [activation function 1 (AF1)], both in isolation and in the context of the intact receptor. AF1 activity in isoform B1 derives from dispersed elements; the B2-specific AF1 consists of a 17-residue amphipathic helix. AF2 function was studied using a two-hybrid assay in Kc cells, based on the observation that potent hormone-dependent activation by the EcR/USP ligand-binding domain heterodimer requires the participation of both partners. Mutagenesis reveals that AF2 function depends on EcR helix 12, but not on the cognate USP region. EcR helix 12 mutants (F645A and W650A) exhibit a dominant negative phenotype. Thus, in the setting tested, the ecdysone receptor can activate transcription using the AF1 regions of EcR-B1 or -B2 and the AF2 region of EcR. USP acts as an allosteric effector for EcR, but does not contribute any intrinsic function." @default.
• W2053982423 created "2016-06-24" @default.
• W2053982423 creator A5008596951 @default.
• W2053982423 creator A5009393718 @default.
• W2053982423 creator A5075853791 @default.
• W2053982423 date "2003-04-01" @default.
• W2053982423 modified "2023-10-07" @default.
• W2053982423 title "Transcription Activation by the Ecdysone Receptor (EcR/USP): Identification of Activation Functions" @default.
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• W2053982423 doi "https://doi.org/10.1210/me.2002-0287" @default.
• W2053982423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12554759" @default.
• W2053982423 hasPublicationYear "2003" @default.
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