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• W2053990807 abstract "The effects of tetrodotoxin, amiloride, phenytoin, aconitine, and tetraethylammonium on isoproterenol- and ACTH-mediated Free Fatty Acids (FFA) and glycerol release from rat adipocytes are investigated in order to understand more about the role of Na+ or K+ in the lipolytic process. Lipolysis induced by 2×10−6 M isoproterenol was mildly affected by the drugs tested. Only tetraethylammonium and aconitine inhibited the lipolytic action of 10−7 M isoproterenol but only slightly. Amiloride significantly enhanced both FFA and glycerol release induced by ACTH. Ionophore X537A inhibited this effect, but the substitution of choline for Na+ or the omission of Ca2+ did not. In these latter experimental conditions, ACTH-mediated lipolysis was strongly inhibited. The sum of these results suggests that the widely observed Na+ and K+ involvement in lipolytic process is independent from operating ion channels in adipocytes." @default.
• W2053990807 created "2016-06-24" @default.
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• W2053990807 date "1982-03-01" @default.
• W2053990807 modified "2023-09-25" @default.
• W2053990807 title "Influences of tetrodotoxin, amiloride, phenytoin, aconitine, tetraethylammonium on ACTH-and isoproterenol-mediated lipolysis in isolated rat adipocytes" @default.
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• W2053990807 doi "https://doi.org/10.1016/s0031-6989(82)80030-1" @default.
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