Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053996795> ?p ?o ?g. }
- W2053996795 endingPage "2260" @default.
- W2053996795 startingPage "2257" @default.
- W2053996795 abstract "Binding of Sonic Hedgehog (Shh) to Patched (Ptc) relieves the latter's tonic inhibition of Smoothened (Smo), a receptor that spans the cell membrane seven times. This initiates signaling which, by unknown mechanisms, regulates vertebrate developmental processes. We find that two molecules interact with mammalian Smo in an activation-dependent manner: G protein–coupled receptor kinase 2 (GRK2) leads to phosphorylation of Smo, and β-arrestin 2 fused to green fluorescent protein interacts with Smo. These two processes promote endocytosis of Smo in clathrin-coated pits. Ptc inhibits association of β-arrestin 2 with Smo, and this inhibition is relieved in cells treated with Shh. A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of β-arrestin 2 with Smo. β-Arrestin 2 and GRK2 are thus potential mediators of signaling by activated Smo." @default.
- W2053996795 created "2016-06-24" @default.
- W2053996795 creator A5005157144 @default.
- W2053996795 creator A5017065880 @default.
- W2053996795 creator A5017541508 @default.
- W2053996795 creator A5021367161 @default.
- W2053996795 creator A5034868635 @default.
- W2053996795 creator A5037500100 @default.
- W2053996795 creator A5075649567 @default.
- W2053996795 creator A5080672788 @default.
- W2053996795 date "2004-12-24" @default.
- W2053996795 modified "2023-10-14" @default.
- W2053996795 title "Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2" @default.
- W2053996795 cites W1486085706 @default.
- W2053996795 cites W1594815607 @default.
- W2053996795 cites W1871313898 @default.
- W2053996795 cites W1895397458 @default.
- W2053996795 cites W1933410007 @default.
- W2053996795 cites W1993416164 @default.
- W2053996795 cites W2002355858 @default.
- W2053996795 cites W2012571494 @default.
- W2053996795 cites W2029500889 @default.
- W2053996795 cites W2030943228 @default.
- W2053996795 cites W2035202152 @default.
- W2053996795 cites W2045106976 @default.
- W2053996795 cites W2049484225 @default.
- W2053996795 cites W2052694810 @default.
- W2053996795 cites W2055296003 @default.
- W2053996795 cites W2067238392 @default.
- W2053996795 cites W2067761409 @default.
- W2053996795 cites W2083334427 @default.
- W2053996795 cites W2085938413 @default.
- W2053996795 cites W2086152184 @default.
- W2053996795 cites W2090455515 @default.
- W2053996795 cites W2097083972 @default.
- W2053996795 cites W2107120297 @default.
- W2053996795 cites W2108707301 @default.
- W2053996795 cites W2118366155 @default.
- W2053996795 cites W2164642954 @default.
- W2053996795 cites W2474599166 @default.
- W2053996795 cites W2614496215 @default.
- W2053996795 doi "https://doi.org/10.1126/science.1104135" @default.
- W2053996795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15618519" @default.
- W2053996795 hasPublicationYear "2004" @default.
- W2053996795 type Work @default.
- W2053996795 sameAs 2053996795 @default.
- W2053996795 citedByCount "265" @default.
- W2053996795 countsByYear W20539967952012 @default.
- W2053996795 countsByYear W20539967952013 @default.
- W2053996795 countsByYear W20539967952014 @default.
- W2053996795 countsByYear W20539967952015 @default.
- W2053996795 countsByYear W20539967952016 @default.
- W2053996795 countsByYear W20539967952017 @default.
- W2053996795 countsByYear W20539967952018 @default.
- W2053996795 countsByYear W20539967952019 @default.
- W2053996795 countsByYear W20539967952020 @default.
- W2053996795 countsByYear W20539967952021 @default.
- W2053996795 countsByYear W20539967952022 @default.
- W2053996795 countsByYear W20539967952023 @default.
- W2053996795 crossrefType "journal-article" @default.
- W2053996795 hasAuthorship W2053996795A5005157144 @default.
- W2053996795 hasAuthorship W2053996795A5017065880 @default.
- W2053996795 hasAuthorship W2053996795A5017541508 @default.
- W2053996795 hasAuthorship W2053996795A5021367161 @default.
- W2053996795 hasAuthorship W2053996795A5034868635 @default.
- W2053996795 hasAuthorship W2053996795A5037500100 @default.
- W2053996795 hasAuthorship W2053996795A5075649567 @default.
- W2053996795 hasAuthorship W2053996795A5080672788 @default.
- W2053996795 hasConcept C11960822 @default.
- W2053996795 hasConcept C135285700 @default.
- W2053996795 hasConcept C139770010 @default.
- W2053996795 hasConcept C145837895 @default.
- W2053996795 hasConcept C170493617 @default.
- W2053996795 hasConcept C185592680 @default.
- W2053996795 hasConcept C2777503648 @default.
- W2053996795 hasConcept C2777994357 @default.
- W2053996795 hasConcept C33235085 @default.
- W2053996795 hasConcept C55493867 @default.
- W2053996795 hasConcept C62478195 @default.
- W2053996795 hasConcept C86803240 @default.
- W2053996795 hasConcept C88498014 @default.
- W2053996795 hasConcept C95444343 @default.
- W2053996795 hasConceptScore W2053996795C11960822 @default.
- W2053996795 hasConceptScore W2053996795C135285700 @default.
- W2053996795 hasConceptScore W2053996795C139770010 @default.
- W2053996795 hasConceptScore W2053996795C145837895 @default.
- W2053996795 hasConceptScore W2053996795C170493617 @default.
- W2053996795 hasConceptScore W2053996795C185592680 @default.
- W2053996795 hasConceptScore W2053996795C2777503648 @default.
- W2053996795 hasConceptScore W2053996795C2777994357 @default.
- W2053996795 hasConceptScore W2053996795C33235085 @default.
- W2053996795 hasConceptScore W2053996795C55493867 @default.
- W2053996795 hasConceptScore W2053996795C62478195 @default.
- W2053996795 hasConceptScore W2053996795C86803240 @default.
- W2053996795 hasConceptScore W2053996795C88498014 @default.
- W2053996795 hasConceptScore W2053996795C95444343 @default.
- W2053996795 hasIssue "5705" @default.
- W2053996795 hasLocation W20539967951 @default.