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• W2054000226 abstract "The mouse ear G2 mitosis assay was modified for the screening of potential antimitotic agents. An inhibitory adrenergic influence, which maintains mitotic rate at a normally low level, was removed by pretreatment of mice with reserpine. This depletes endogenous catecholamines, produces a state of enhanced mitotic activity, and makes the epidermal cells particularly sensitive to mitotic inhibition by agents which elevate the levels of cyclic AMP. Isoproterenol [IC 50 approximately 1 X 10(-9) M], prostaglandins, dibutyryl cyclic AMP [IC 50 approximately 2 X 10(-5) M], papaverine, theophylline and 5' AMP were inhibitory in the assay, whereas dibutyryl cyclic GMP and the cholinergic stimulator carbamylcholine either stimulated or had no effect on mitosis. Epidermal growth factor was employed as an alternate means of stimulating cell division. Skin fron newborn mice or rats pretreated with this substance had increased epidermal mitotic activity which was inhibited cyclic AMP elevators." @default.
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• W2054000226 date "1976-05-01" @default.
• W2054000226 modified "2023-09-30" @default.
• W2054000226 title "Effects Of Resperpine, Epidermal Growth Factor, And Cyclic Nucleotide Modulators On Epidermal Mitosis" @default.
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• W2054000226 doi "https://doi.org/10.1111/1523-1747.ep12482297" @default.
• W2054000226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/178806" @default.
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