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• W2054004792 abstract "Mice provide a range of important models of human disease. As part of a broad program of metabolic phenotyping (metabotyping) the effects of gender and strain upon urinary metabolite composition and variation have been investigated using 1H NMR spectroscopy and chemometrics in the Alpk:ApfCD, C57BL10J and the “Nude mouse”. By using Principal Components Analysis (PCA) and Soft Independent Modeling by Class Analogy (SIMCA), characteristic metabotypes for each strain were produced for both male and female animals. In all three strains, female urinary metabolic profiles were characterized by higher lactate, trimethylamine-N-oxide and lower trimethylamine concentrations relative to males. Both male and female Nude mice were phenotypically distinct from the Alpk:ApfCD and C57BL10J strainsthe Nude mouse phenotypes being characterized by higher urinary creatinine, guanadinoacetic acid, dimethylamine, α-hydroxy-N-valeric acid and taurine levels and lower hippurate, citrate, creatine and succinate concentrations relative to those excreted by the two phenotypically normal mouse strains. These data show that Nude mice exhibit a wide variety of metabolic differences across a much wider range of pathways than has previously been thought, with potentially important considerations for studies that use the Nude mouse as a mouse model. Keywords: metabotype • molecular phenotype • metabonomics • 1H NMR spectroscopy • strain difference • gender variation • Nude mouse" @default.
• W2054004792 created "2016-06-24" @default.
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• W2054004792 date "2006-01-19" @default.
• W2054004792 modified "2023-10-18" @default.
• W2054004792 title "Metabolic Phenotyping of Nude and Normal (Alpk:ApfCD, C57BL10J) Mice" @default.
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• W2054004792 doi "https://doi.org/10.1021/pr050255h" @default.
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