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- W2054005121 abstract "The mortality and morbidity of neonatal GBS disease remain significant, even with optimal antibiotic therapy. Recently, with the availability of several ISG preparations modified for iv administration, use of this material as therapeutic adjunct has been suggested. However, it is not known whether ISG modified by different methods will have similar biological activity. We compared functional activities in vitro and in vivo of two ISG modified for iv use against a type III GBS, reduced and alkylated (RA) and native (N) ISGs. Both preparations (5%) contained similar amounts of type III (4.0 vs 4.8 μg/ml) and group B (49.5 and 49.8 μg/ml) streptococcal antibodies of IgG class measured by the ELISA. IgM and IgA antibodies were undectable. In vivo, we used the newborn rat model of GBS bacteremia and meningitis. Five-day-old rats received ip 10-fold diluted RA or N ISG in a dose of 50 μl/10 gm and then sc LD100 of the GBS strain. Mortality was recorded for 5 days and blood cultures done in dead animals. The 50% protective dose (dilution) was 1:4 for RA ISG vs 1:16 for N ISG. In vitro studies measured phagocytosis and killing of the GBS strain by rat PMNs in the presence of ISG and rat complement. Efficient opsonophagocytosis (≥90% killing) occurred with ≤10−3 dilution of RA ISG vs ≤10−4 dilution of N ISG. The findings suggest that RA ISG is less active than N ISG against type III GBS. Further studies are needed to understand the mechanisms responsible for this apparent discrepancy in functional activity of RA and N ISGs." @default.
- W2054005121 created "2016-06-24" @default.
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- W2054005121 date "1985-04-01" @default.
- W2054005121 modified "2023-09-26" @default.
- W2054005121 title "1121 IN VITRO AND IN VIVO STUDIES OF HUMAN IMMUNE SERUM GLOBULIN (ISG) MODIFIED FOR INTRAVENOUS USE AGAINST TYPE III GROUP B STREPTOCOCCUS (GBS)" @default.
- W2054005121 doi "https://doi.org/10.1203/00006450-198504000-01151" @default.
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