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- W2054010368 abstract "In human neutrophils, significant agonist‐stimulated superoxide anion (O − 2 ) release is observed only after exposure to a priming agent such as TNFα. We have investigated the potential for TNFα to modulate N ‐formyl‐Met‐Leu‐Phe (fMLP)‐triggered Ins(1,4,5)P 3 and PtdIns(3,4,5)P 3 accumulation. TNFα pretreatment did not affect basal or stimulated Ins(1,4,5)P 3 levels but greatly upregulated fMLP‐stimulated PtdIns(3,4,5)P 3 accumulation, in a manner that matched, both temporally and in magnitude, the increase in O − 2 generation implying a possible role for PtdIns(3,4,5)P 3 in signalling primed O − 2 release." @default.
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- W2054010368 date "1998-11-13" @default.
- W2054010368 modified "2023-10-17" @default.
- W2054010368 title "Priming of human neutrophil superoxide generation by tumour necrosis factor‐α is signalled by enhanced phosphatidylinositol 3,4,5‐trisphosphate but not inositol 1,4,5‐trisphosphate accumulation" @default.
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- W2054010368 doi "https://doi.org/10.1016/s0014-5793(98)01358-1" @default.
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