FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054011804> ?p ?o ?g. }

• W2054011804 endingPage "21698" @default.
• W2054011804 startingPage "21686" @default.
• W2054011804 abstract "MicroRNAs (miRNAs) mainly function as post-transcriptional regulators and are involved in a wide range of physiological and pathophysiological processes such as cell proliferation, differentiation, apoptosis, and tumorigenesis. Mouse testes express a large number of miRNAs. However, the physiological roles of these testicular miRNAs remain largely unknown. Using microarray and quantitative real time PCR assays, we identified that miRNAs of the microRNA-449 (miR-449) cluster were preferentially expressed in the mouse testis, and their levels were drastically up-regulated upon meiotic initiation during testicular development and in adult spermatogenesis. The expression pattern of the miR-449 cluster resembled that of microRNA-34b/c (miR-34b/c) during spermatogenesis. Further analyses identified that cAMP-responsive element modulator τ and SOX5, two transcription factors essential for regulating male germ cell gene expression, acted as the upstream transactivators to stimulate the expression of the miR-449 cluster in mouse testes. Despite its abundant expression in testicular germ cells, miR-449-null male mice developed normally and exhibited normal spermatogenesis and fertility. Our data further demonstrated that miR-449 shared a cohort of target genes that belong to the E2F transcription factor-retinoblastoma protein pathway with the miR-34 family, and levels of miR-34b/c were significantly up-regulated in miR-449-null testes. Taken together, our data suggest that the miR-449 cluster and miR-34b/c function redundantly in the regulation of male germ cell development in murine testes." @default.
• W2054011804 created "2016-06-24" @default.
• W2054011804 creator A5000773794 @default.
• W2054011804 creator A5005381760 @default.
• W2054011804 creator A5006823146 @default.
• W2054011804 creator A5011616753 @default.
• W2054011804 creator A5012278873 @default.
• W2054011804 creator A5019462695 @default.
• W2054011804 creator A5034127863 @default.
• W2054011804 creator A5037458498 @default.
• W2054011804 creator A5042346357 @default.
• W2054011804 creator A5081855564 @default.
• W2054011804 creator A5086210898 @default.
• W2054011804 date "2012-06-01" @default.
• W2054011804 modified "2023-10-11" @default.
• W2054011804 title "MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway" @default.
• W2054011804 cites W1866072251 @default.
• W2054011804 cites W1968631483 @default.
• W2054011804 cites W1969003435 @default.
• W2054011804 cites W1969701330 @default.
• W2054011804 cites W1975850106 @default.
• W2054011804 cites W1978682491 @default.
• W2054011804 cites W1986299882 @default.
• W2054011804 cites W1986317453 @default.
• W2054011804 cites W1990609264 @default.
• W2054011804 cites W1991425207 @default.
• W2054011804 cites W1991674206 @default.
• W2054011804 cites W1992508898 @default.
• W2054011804 cites W1993199813 @default.
• W2054011804 cites W2001502548 @default.
• W2054011804 cites W2004219747 @default.
• W2054011804 cites W2007612364 @default.
• W2054011804 cites W2012319310 @default.
• W2054011804 cites W2013868665 @default.
• W2054011804 cites W2014510815 @default.
• W2054011804 cites W2022120773 @default.
• W2054011804 cites W2022839356 @default.
• W2054011804 cites W2025975633 @default.
• W2054011804 cites W2029040687 @default.
• W2054011804 cites W2032096932 @default.
• W2054011804 cites W2032796181 @default.
• W2054011804 cites W2033595939 @default.
• W2054011804 cites W2046486243 @default.
• W2054011804 cites W2053834034 @default.
• W2054011804 cites W2058546920 @default.
• W2054011804 cites W2060418170 @default.
• W2054011804 cites W2065731929 @default.
• W2054011804 cites W2067977943 @default.
• W2054011804 cites W2070032322 @default.
• W2054011804 cites W2070319253 @default.
• W2054011804 cites W2070765029 @default.
• W2054011804 cites W2082171629 @default.
• W2054011804 cites W2083158631 @default.
• W2054011804 cites W2085442947 @default.
• W2054011804 cites W2091755990 @default.
• W2054011804 cites W2093364931 @default.
• W2054011804 cites W2099715131 @default.
• W2054011804 cites W2109712459 @default.
• W2054011804 cites W2111629903 @default.
• W2054011804 cites W2113635738 @default.
• W2054011804 cites W2121758843 @default.
• W2054011804 cites W2123159256 @default.
• W2054011804 cites W2123356446 @default.
• W2054011804 cites W2128500967 @default.
• W2054011804 cites W2130522127 @default.
• W2054011804 cites W2137916429 @default.
• W2054011804 cites W2140694202 @default.
• W2054011804 cites W2147672884 @default.
• W2054011804 cites W2148848936 @default.
• W2054011804 cites W2149146453 @default.
• W2054011804 cites W2150013759 @default.
• W2054011804 cites W2153844934 @default.
• W2054011804 cites W2165717626 @default.
• W2054011804 cites W2321525112 @default.
• W2054011804 cites W2333541014 @default.
• W2054011804 cites W31788419 @default.
• W2054011804 doi "https://doi.org/10.1074/jbc.m111.328054" @default.
• W2054011804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3381132" @default.
• W2054011804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22570483" @default.
• W2054011804 hasPublicationYear "2012" @default.
• W2054011804 type Work @default.
• W2054011804 sameAs 2054011804 @default.
• W2054011804 citedByCount "183" @default.
• W2054011804 countsByYear W20540118042012 @default.
• W2054011804 countsByYear W20540118042013 @default.
• W2054011804 countsByYear W20540118042014 @default.
• W2054011804 countsByYear W20540118042015 @default.
• W2054011804 countsByYear W20540118042016 @default.
• W2054011804 countsByYear W20540118042017 @default.
• W2054011804 countsByYear W20540118042018 @default.
• W2054011804 countsByYear W20540118042019 @default.
• W2054011804 countsByYear W20540118042020 @default.
• W2054011804 countsByYear W20540118042021 @default.
• W2054011804 countsByYear W20540118042022 @default.
• W2054011804 countsByYear W20540118042023 @default.
• W2054011804 crossrefType "journal-article" @default.
• W2054011804 hasAuthorship W2054011804A5000773794 @default.
• W2054011804 hasAuthorship W2054011804A5005381760 @default.

• next