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• W2054012790 abstract "<i>Background/Aims:</i> Volatile anesthetics are frequently utilized in clinical routine. Isoflurane has been shown to attenuate the response to inflammatory stimuli such as lipopolysaccharide (LPS) when administered <i>before</i> induction of endotoxemia. We aimed therefore to evaluate the effect of isoflurane <i>after</i> administration of LPS on the cytokine release as a therapeutic option. <i>Materials and Methods:</i>21 male Sprague-Dawley rats were randomly assigned to the following groups: animals that received LPS (5 mg/kg, i.v.) without further intervention (LPS group), animals that received continuous inhalation of 1 minimum alveolar concentration (MAC) isoflurane 15 min after administration of LPS (Iso group) and no specific intervention (sham group). Four hours following LPS injection, plasma levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6 and IL-10 were determined. Furthermore, nitrite release from cultured alveolar macrophages was analyzed. <i>Results:</i> Inhalation of isoflurane after induction of endotoxemia attenuated the release of TNF-α (–52%, p < 0.05) and IL-1β (–39%, p < 0.05) as compared to the LPS group, while IL-6 and IL-10 levels were not significantly altered. Nitrite release was significantly increased in the Iso group as compared to the LPS group (+115%, p < 0.05). <i>Conclusion:</i> Inhalation of 1 MAC isoflurane after induction of endotoxemia in rats attenuates the systemic release of proinflammatory cytokines and concurrently enhances the production of nitrite in cultured alveolar macrophages." @default.
• W2054012790 created "2016-06-24" @default.
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• W2054012790 date "2007-08-23" @default.
• W2054012790 modified "2023-10-02" @default.
• W2054012790 title "Isoflurane Inhalation after Induction of Endotoxemia in Rats Attenuates the Systemic Cytokine Response" @default.
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• W2054012790 doi "https://doi.org/10.1159/000107614" @default.
• W2054012790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17717418" @default.
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