FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054033311> ?p ?o ?g. }

• W2054033311 endingPage "335" @default.
• W2054033311 startingPage "329" @default.
• W2054033311 abstract "There are a number of observations that suggest the dsRNA-activated protein kinase, PKR, may play an active role in formation and maintenance of leukemia, including nonrandom chromosomal deletions in acute leukemia as well as truncations and deletions of the PKR gene in some leukemia cell lines. However, there is little direct evidence from patient material that this is so. Here we show that full-length PKR is present but not active in 21 of 28 patient samples from B-cell chronic lymphocytic leukemia (B-CLL). PKR from these patients was unable to auto-activate or phosphorylate substrates but was able to bind dsRNA. Furthermore, the lack of PKR activation was not due to differing levels of the PKR activator, PACT nor of the PKR inhibitor, p58(IPK). We compared PKR status with clinical parameters and disease staging. No differences were found between the 2 groups in terms of staging (modified Rai or Binet), age, CD38 status, p53 status, 11q23 deletion status or CEP12 deletion status. However, there was a significant correlation between deletion in 13q14.3 and lack of PKR activity. We show that B-CLL cells appear to contain a soluble inhibitor of PKR, as lysates from cells lacking PKR activity were able to inhibit exogenous PKR in mixing experiments. Finally, we show suppression of PKR activity was still present following ultrafilitration through a 10,000 Da cutoff filter but was lost upon extraction with phenol/chloroform or by high salt washing. This data suggests loss of PKR activity may contribute to the formation and/or maintenance of CLL." @default.
• W2054033311 created "2016-06-24" @default.
• W2054033311 creator A5013082647 @default.
• W2054033311 creator A5020987248 @default.
• W2054033311 creator A5027054405 @default.
• W2054033311 creator A5028093441 @default.
• W2054033311 creator A5039779160 @default.
• W2054033311 creator A5073169676 @default.
• W2054033311 creator A5079324561 @default.
• W2054033311 date "2004-01-09" @default.
• W2054033311 modified "2023-10-10" @default.
• W2054033311 title "Loss of PKR activity in chronic lymphocytic leukemia" @default.
• W2054033311 cites W154103547 @default.
• W2054033311 cites W1569857352 @default.
• W2054033311 cites W1589415602 @default.
• W2054033311 cites W1598544178 @default.
• W2054033311 cites W179070074 @default.
• W2054033311 cites W185768814 @default.
• W2054033311 cites W1965851569 @default.
• W2054033311 cites W1970812281 @default.
• W2054033311 cites W1972211816 @default.
• W2054033311 cites W1976963563 @default.
• W2054033311 cites W1998008247 @default.
• W2054033311 cites W2005968120 @default.
• W2054033311 cites W2015892707 @default.
• W2054033311 cites W2021937067 @default.
• W2054033311 cites W2022969546 @default.
• W2054033311 cites W2023400811 @default.
• W2054033311 cites W2041164581 @default.
• W2054033311 cites W2041278917 @default.
• W2054033311 cites W2042772639 @default.
• W2054033311 cites W2045046145 @default.
• W2054033311 cites W2047391267 @default.
• W2054033311 cites W2057411341 @default.
• W2054033311 cites W2060962038 @default.
• W2054033311 cites W2068164861 @default.
• W2054033311 cites W2070622761 @default.
• W2054033311 cites W2070857656 @default.
• W2054033311 cites W2071700771 @default.
• W2054033311 cites W2077198961 @default.
• W2054033311 cites W2085622324 @default.
• W2054033311 cites W2087479365 @default.
• W2054033311 cites W2089033636 @default.
• W2054033311 cites W2089835533 @default.
• W2054033311 cites W2090780358 @default.
• W2054033311 cites W2097803333 @default.
• W2054033311 cites W2130485280 @default.
• W2054033311 cites W2145742501 @default.
• W2054033311 cites W2156065951 @default.
• W2054033311 cites W2160362784 @default.
• W2054033311 cites W2161832141 @default.
• W2054033311 cites W2166497605 @default.
• W2054033311 cites W2335061472 @default.
• W2054033311 cites W2396068685 @default.
• W2054033311 cites W4252861813 @default.
• W2054033311 cites W51918105 @default.
• W2054033311 cites W72105427 @default.
• W2054033311 doi "https://doi.org/10.1002/ijc.11714" @default.
• W2054033311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14961569" @default.
• W2054033311 hasPublicationYear "2004" @default.
• W2054033311 type Work @default.
• W2054033311 sameAs 2054033311 @default.
• W2054033311 citedByCount "44" @default.
• W2054033311 countsByYear W20540333112012 @default.
• W2054033311 countsByYear W20540333112013 @default.
• W2054033311 countsByYear W20540333112014 @default.
• W2054033311 countsByYear W20540333112015 @default.
• W2054033311 countsByYear W20540333112016 @default.
• W2054033311 countsByYear W20540333112017 @default.
• W2054033311 countsByYear W20540333112018 @default.
• W2054033311 countsByYear W20540333112019 @default.
• W2054033311 countsByYear W20540333112020 @default.
• W2054033311 countsByYear W20540333112022 @default.
• W2054033311 countsByYear W20540333112023 @default.
• W2054033311 crossrefType "journal-article" @default.
• W2054033311 hasAuthorship W2054033311A5013082647 @default.
• W2054033311 hasAuthorship W2054033311A5020987248 @default.
• W2054033311 hasAuthorship W2054033311A5027054405 @default.
• W2054033311 hasAuthorship W2054033311A5028093441 @default.
• W2054033311 hasAuthorship W2054033311A5039779160 @default.
• W2054033311 hasAuthorship W2054033311A5073169676 @default.
• W2054033311 hasAuthorship W2054033311A5079324561 @default.
• W2054033311 hasConcept C104317684 @default.
• W2054033311 hasConcept C161238802 @default.
• W2054033311 hasConcept C184235292 @default.
• W2054033311 hasConcept C203014093 @default.
• W2054033311 hasConcept C2777479484 @default.
• W2054033311 hasConcept C2778461978 @default.
• W2054033311 hasConcept C502942594 @default.
• W2054033311 hasConcept C55493867 @default.
• W2054033311 hasConcept C82495950 @default.
• W2054033311 hasConcept C86803240 @default.
• W2054033311 hasConcept C88045685 @default.
• W2054033311 hasConcept C90934575 @default.
• W2054033311 hasConcept C97029542 @default.
• W2054033311 hasConceptScore W2054033311C104317684 @default.
• W2054033311 hasConceptScore W2054033311C161238802 @default.
• W2054033311 hasConceptScore W2054033311C184235292 @default.

• next