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- W2054035115 abstract "Many years ago, the author suggested that the plasma proteins, now called immunoglobulins, were not necessarily a particular “defense mechanism” but a physiological system of “transporteurs” of catabolic and metabolic products, these last corresponding to the “not self” antigens. In recent years, the existence of normal auto-antibodies and their frequent appearance in various conditions (particularly when an abundant destruction of tissue occurs) have been amply demonstrated. In contrast to other theories of the mechanism of recognition of self antigens, the author considers that in normal conditions these components are degraded by autolytic enzymes: therefore no activation of the corresponding immuno-competent cells take place. In cases of massive destruction of tissues or cells the enzyme activity is inhibited by the excess of substrate and the non-degraded auto-antigens induce the formation of auto-antibodies by the corresponding cells, which persist normally in the organism. Therefore, there is no need to imagine a particular mechanism for the actual synthesis of antibodies for self antigens. The possible role of enzyme degradation in immunological unresponsiveness is discussed. As auto-antibodies are specific “transporteurs” of catabolic products, their existence represents an additional argument for the original proposal." @default.
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- W2054035115 date "1975-09-01" @default.
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- W2054035115 title "The “globulines-transporteurs” theory and auto-sensitization" @default.
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- W2054035115 doi "https://doi.org/10.1016/0306-9877(75)90045-6" @default.
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