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- W2054051948 abstract "37 Background. NHL, especially enteropathy associated T-cell lymphoma (EATL), is a possible long term complication of CD. However, the CD-associated risk of NHL has not been accurately measured. The prevalence of lymphoma complicating CD was 0-18% in previous studies. Aim: a) to quantify the risk of NHL in patients with CD; b) to characterize the spectrum of CD-associated NHL. Study-design. Multicentre case-control study. Cases: subjects over 20 with NHL at the onset of any primary site and histological type. Controls: population control series of adult Italians. Algorithm: a) collection of detailed clinical information; b) serum IgA antiendomysium antibodies (IgA-AEA) testing: c) intestinal biopsy in AEA positive cases. Results. Between Jan 96-Sept 98, 446 NHLs were enrolled: 259 M and 187 F with a median age of 55.9 yrs (range: 20-28). NHL was localized (67%) or disseminated (33%); of B (77%), T cell (9%), not specified (14%) origin; primarily in the gut: 55(12%). The diagnosis of associated CD was established in 4 cases (with EATL, ileal B cell, small intestine T cell and mediastinum T cell NHL respectively) and suspected in 2 further cases (with stomach B cell and tonsil T cell respectively). Two patients with disseminated T cell NHL showed serum AEA positivity with a normal jejunal histology (potential CD). In the control group (n=5098) there were 15 CD cases. The OR of NHL (adjusted for age and gender) was 4.1 (95% CI 1.4-11.8) considering only proven CD cases and 8.2 (3.7-18.0) including probable and potential CD cases. Conclusion: a) patients with CD show an increased risk of NHL at any primary site compared with the general population; however the risk seems to be lower than previously estimated; b) CD-associated NHLs include not only EATL but also a spectrum of T cell or B cell forms with intestinal or extra-intestinal sites." @default.
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- W2054051948 date "1999-05-01" @default.
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- W2054051948 title "THE RISK OF NHL IN PATIENTS WITH CD: PRELIMINARY RESULTS OF THE ITALIAN MULTICENTRE STUDY" @default.
- W2054051948 doi "https://doi.org/10.1097/00005176-199905000-00059" @default.
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