FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054053393> ?p ?o ?g. }

• W2054053393 endingPage "273" @default.
• W2054053393 startingPage "268" @default.
• W2054053393 abstract "We synthesized the 26-residue deoxynucleotide sequence d(TTCCT5GGAATTCCT5GGAA) which folds intramolecularly to form a dumbbell-shaped, double-hairpin structure with a gap between the 3' and the 5' ends. We used T4 polynucleotide kinase to phosphorylate the 5' end followed by T4 DNA ligase to close the 3' and 5' ends. Melting of the dumbbell structure formed by this ligated sequence produces a covalently closed, single-stranded, circular final state. We employed calorimetric and spectroscopic techniques to characterize thermodynamically the melting behavior of the ligated molecule and compared it with the corresponding melting behavior of its unligated precursor. This comparison allowed us to characterize uniquely the influence of single-stranded ring closure on intramolecular duplex melting. The data reveal that ring closure produces a thermally more stable structure which exhibits significantly altered melting thermodynamics. We rationalize these thermodynamic differences in terms of differential solvation and differential counterion association between the ligated and unligated molecules. We also note the importance of such constrained dumbbell structures as models for hairpins, cruciforms, and locally melted domains within naturally occurring DNA polymers." @default.
• W2054053393 created "2016-06-24" @default.
• W2054053393 creator A5028433460 @default.
• W2054053393 creator A5032779622 @default.
• W2054053393 creator A5055527433 @default.
• W2054053393 creator A5060529789 @default.
• W2054053393 creator A5083311745 @default.
• W2054053393 date "1989-01-10" @default.
• W2054053393 modified "2023-10-17" @default.
• W2054053393 title "Melting behavior of a covalently closed, single-stranded, circular DNA" @default.
• W2054053393 cites W1518002808 @default.
• W2054053393 cites W1577332561 @default.
• W2054053393 cites W1582219327 @default.
• W2054053393 cites W1586563423 @default.
• W2054053393 cites W1966335651 @default.
• W2054053393 cites W1970205873 @default.
• W2054053393 cites W1976409387 @default.
• W2054053393 cites W1979454155 @default.
• W2054053393 cites W1996106502 @default.
• W2054053393 cites W2009095852 @default.
• W2054053393 cites W2010998826 @default.
• W2054053393 cites W2013562725 @default.
• W2054053393 cites W2025936873 @default.
• W2054053393 cites W2026884660 @default.
• W2054053393 cites W2028753366 @default.
• W2054053393 cites W2029062701 @default.
• W2054053393 cites W2030725755 @default.
• W2054053393 cites W2036203264 @default.
• W2054053393 cites W2043619056 @default.
• W2054053393 cites W2071138881 @default.
• W2054053393 cites W2075031558 @default.
• W2054053393 cites W2084286730 @default.
• W2054053393 cites W2085283827 @default.
• W2054053393 cites W2086104856 @default.
• W2054053393 cites W2093506772 @default.
• W2054053393 cites W2096577501 @default.
• W2054053393 cites W2096948571 @default.
• W2054053393 cites W2142401829 @default.
• W2054053393 cites W2177743694 @default.
• W2054053393 cites W2322672979 @default.
• W2054053393 cites W74400302 @default.
• W2054053393 doi "https://doi.org/10.1021/bi00427a037" @default.
• W2054053393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2706250" @default.
• W2054053393 hasPublicationYear "1989" @default.
• W2054053393 type Work @default.
• W2054053393 sameAs 2054053393 @default.
• W2054053393 citedByCount "60" @default.
• W2054053393 countsByYear W20540533932012 @default.
• W2054053393 countsByYear W20540533932016 @default.
• W2054053393 countsByYear W20540533932018 @default.
• W2054053393 countsByYear W20540533932020 @default.
• W2054053393 countsByYear W20540533932021 @default.
• W2054053393 countsByYear W20540533932022 @default.
• W2054053393 countsByYear W20540533932023 @default.
• W2054053393 crossrefType "journal-article" @default.
• W2054053393 hasAuthorship W2054053393A5028433460 @default.
• W2054053393 hasAuthorship W2054053393A5032779622 @default.
• W2054053393 hasAuthorship W2054053393A5055527433 @default.
• W2054053393 hasAuthorship W2054053393A5060529789 @default.
• W2054053393 hasAuthorship W2054053393A5083311745 @default.
• W2054053393 hasConcept C111921641 @default.
• W2054053393 hasConcept C175114707 @default.
• W2054053393 hasConcept C178790620 @default.
• W2054053393 hasConcept C180577832 @default.
• W2054053393 hasConcept C185592680 @default.
• W2054053393 hasConcept C2776546559 @default.
• W2054053393 hasConcept C32909587 @default.
• W2054053393 hasConcept C42407357 @default.
• W2054053393 hasConcept C552990157 @default.
• W2054053393 hasConcept C55493867 @default.
• W2054053393 hasConcept C8010536 @default.
• W2054053393 hasConcept C86803240 @default.
• W2054053393 hasConcept C99611785 @default.
• W2054053393 hasConceptScore W2054053393C111921641 @default.
• W2054053393 hasConceptScore W2054053393C175114707 @default.
• W2054053393 hasConceptScore W2054053393C178790620 @default.
• W2054053393 hasConceptScore W2054053393C180577832 @default.
• W2054053393 hasConceptScore W2054053393C185592680 @default.
• W2054053393 hasConceptScore W2054053393C2776546559 @default.
• W2054053393 hasConceptScore W2054053393C32909587 @default.
• W2054053393 hasConceptScore W2054053393C42407357 @default.
• W2054053393 hasConceptScore W2054053393C552990157 @default.
• W2054053393 hasConceptScore W2054053393C55493867 @default.
• W2054053393 hasConceptScore W2054053393C8010536 @default.
• W2054053393 hasConceptScore W2054053393C86803240 @default.
• W2054053393 hasConceptScore W2054053393C99611785 @default.
• W2054053393 hasIssue "1" @default.
• W2054053393 hasLocation W20540533931 @default.
• W2054053393 hasLocation W20540533932 @default.
• W2054053393 hasOpenAccess W2054053393 @default.
• W2054053393 hasPrimaryLocation W20540533931 @default.
• W2054053393 hasRelatedWork W1575341303 @default.
• W2054053393 hasRelatedWork W1973233877 @default.
• W2054053393 hasRelatedWork W1981247025 @default.
• W2054053393 hasRelatedWork W1994440864 @default.
• W2054053393 hasRelatedWork W2009940574 @default.
• W2054053393 hasRelatedWork W2012383858 @default.
• W2054053393 hasRelatedWork W2048858225 @default.

• next