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• W2054063485 abstract "The time course and mechanisms of adjustment of pulmonary oxygen uptake (V̇o 2 ) kinetics (time constant τV̇o 2p ) were examined during step transitions from 20 W to moderate-intensity cycling in eight older men (O; 68 ± 7 yr) and eight young men (Y; 23 ± 5 yr) before training and at 3, 6, 9, and 12 wk of endurance training. V̇o 2p was measured breath by breath with a volume turbine and a mass spectrometer. Changes in deoxygenated hemoglobin concentration (Δ[HHb]) were measured by near-infrared spectroscopy. V̇o 2p and Δ[HHb] were modeled with a monoexponential model. Training was performed on a cycle ergometer three times per week for 45 min at ∼70% of peak V̇o 2 . Pretraining τV̇o 2p was greater ( P < 0.05) in O (43 ± 10 s) than Y (34 ± 8 s). τV̇o 2p decreased ( P < 0.05) by 3 wk of training in both O (35 ± 9 s) and Y (22 ± 8 s), with no further changes thereafter. The pretraining overall adjustment of Δ[HHb] was faster than τV̇o 2p in both O and Y, resulting in Δ[HHb]/V̇o 2p displaying an “overshoot” during the transient relative to the subsequent steady-state level. After 3 wk of training the Δ[HHb]/V̇o 2p overshoot was attenuated in both O and Y. With further training, this overshoot persisted in O but was eliminated after 6 wk in Y. The training-induced speeding of V̇o 2p kinetics in O and Y at 3 wk of training was associated with an improved matching of local O 2 delivery to muscle V̇o 2 (as represented by a lower Δ[HHb]/V̇o 2p ). The continued overshoot in Δ[HHb]/V̇o 2p in O may reflect a reduced vasodilatory responsiveness that may limit muscle blood flow distribution during the on-transient of exercise." @default.
• W2054063485 created "2016-06-24" @default.
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• W2054063485 date "2010-04-01" @default.
• W2054063485 modified "2023-09-24" @default.
• W2054063485 title "Speeding of V̇<scp>o</scp>₂ kinetics with endurance training in old and young men is associated with improved matching of local O₂ delivery to muscle O₂ utilization" @default.
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• W2054063485 doi "https://doi.org/10.1152/japplphysiol.01355.2009" @default.
• W2054063485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2853203" @default.
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