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• W2054066181 abstract "KW-3902, 1, 3-dipropyl-8-(3-noradamantanyl) xanthine, is a novel potent and selective adenosine A1-receptor antagonist. KW-3902 has been found to cause significant diuresis and natriuresis. To investigate the action of this adenosine A1-receptor antagonist on phosphate transport in renal proximal tubular cells, we studied its effect on the uptake of phosphate by the cultured rat renal proximal tubular cell. KW-3902 significantly inhibited sodium-dependent uptake of phosphate at 10 minutes. The inhibitory effect was dose-dependent with maximum effect achieved at a KW-3902 concentration of 3×10−5 M in the uptake media. The half-maximal inhibitory concentration, IC50, of KW-3902 on phosphate uptake was 2×10−6 M. Dixon plot analysis op the uptake data was consistent with pure non-competitive inhibition. The inhibition constant, Ki, of 6.2×10−6 M for phosphate transport, derived from Dixon plot, was in close agreement with the IC50 calculated from a semilog dose response curve. Sodium-dependent glucose transport was not affected by KW-3902. These findings reveal that KW-3902 has a direct and specific inhibitory effect on phosphate uptake in renal proximal tubules." @default.
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• W2054066181 date "1994-01-01" @default.
• W2054066181 modified "2023-09-25" @default.
• W2054066181 title "Effect of KW-3902, a novel adenosine A1 receptor antagonist, on sodium-dependent phosphate and glucose transport by the rat renal proximal tubular" @default.
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• W2054066181 doi "https://doi.org/10.1016/0024-3205(94)00567-2" @default.
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