FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054068500> ?p ?o ?g. }

• W2054068500 endingPage "4521" @default.
• W2054068500 startingPage "4521" @default.
• W2054068500 abstract "Itraconazole (ITZ) is a synthetic triazole antifungal agent, which is widely used for treatment and prevention of fungal infections. The purpose of this study is to develop ITZ-loaded poly(lactic-co-glycolic acid) (PLGA) nanospheres (PLGA-ITZ-NS) as a new sustained-release formulation for intravenous ITZ administration.PLGA-ITZ-NS were prepared by a nanoprecipitation method and optimized by modifying the surfactant poloxamer 188 concentration and PLGA:ITZ ratio. Their physicochemical properties, including size, zeta potential, external morphology and encapsulation efficiency, were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC). The effect of the different selected lyoprotectants with various concentrations on NS particles size and surface charge were also assessed. Rapid and sensitive HPLC and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed to determine ITZ concentrations in formulation and in rat plasma, respectively. Pharmacokinetics of the optimum PLGA-ITZ-NS formulation was compared with the former commercial Sporanox® injection formulation using rats as the animal model. Noncompartmental pharmacokinetic parameters were obtained by WinNonlin® software.Optimal PLGA-ITZ-NS had a mean particle size of about 200 nm with a high homogeneity (polydispersity index ≈0.2), favorable zeta potential (approximately -20 to -30 mV) and encapsulation efficiency (72%). In addition, 2% w/v sucrose was selected as a lyoprotectant for NS freeze-drying. The newly developed LC-MS/MS assay was validated and found to be accurate and precise. The in vivo study showed that the NS formulation has a similar systemic bioavailability to Sporanox® while providing a sustained plasma level (> 100 ng/mL) for up to 24 hours after intravenous administration.Our newly developed PLGA-ITZ-NS has shown great sustained release and comparable bioavailability with Sporanox®, therefore having the potential to be an alternative injectable formulation of ITZ." @default.
• W2054068500 created "2016-06-24" @default.
• W2054068500 creator A5000302734 @default.
• W2054068500 creator A5017620945 @default.
• W2054068500 creator A5023437328 @default.
• W2054068500 creator A5048765188 @default.
• W2054068500 creator A5052549091 @default.
• W2054068500 creator A5060346162 @default.
• W2054068500 creator A5083662293 @default.
• W2054068500 date "2013-11-01" @default.
• W2054068500 modified "2023-09-25" @default.
• W2054068500 title "Development of PLGA-based itraconazole injectable nanospheres for sustained release" @default.
• W2054068500 cites W1264540065 @default.
• W2054068500 cites W186519247 @default.
• W2054068500 cites W1965881735 @default.
• W2054068500 cites W1970163124 @default.
• W2054068500 cites W1976795612 @default.
• W2054068500 cites W1977402294 @default.
• W2054068500 cites W1983852511 @default.
• W2054068500 cites W1984146494 @default.
• W2054068500 cites W1995169732 @default.
• W2054068500 cites W2000040262 @default.
• W2054068500 cites W2007445878 @default.
• W2054068500 cites W2013585426 @default.
• W2054068500 cites W2019789038 @default.
• W2054068500 cites W2020398834 @default.
• W2054068500 cites W2020508149 @default.
• W2054068500 cites W2020747873 @default.
• W2054068500 cites W2021321721 @default.
• W2054068500 cites W2023079697 @default.
• W2054068500 cites W2038850098 @default.
• W2054068500 cites W2066403337 @default.
• W2054068500 cites W2070029492 @default.
• W2054068500 cites W2078534693 @default.
• W2054068500 cites W2080727509 @default.
• W2054068500 cites W2108461317 @default.
• W2054068500 cites W2112931872 @default.
• W2054068500 cites W2116183504 @default.
• W2054068500 cites W2136119587 @default.
• W2054068500 cites W2143302080 @default.
• W2054068500 cites W2144907950 @default.
• W2054068500 cites W2151464620 @default.
• W2054068500 cites W2160473317 @default.
• W2054068500 cites W2163121767 @default.
• W2054068500 cites W2325453579 @default.
• W2054068500 doi "https://doi.org/10.2147/ijn.s54040" @default.
• W2054068500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3839800" @default.
• W2054068500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24311942" @default.
• W2054068500 hasPublicationYear "2013" @default.
• W2054068500 type Work @default.
• W2054068500 sameAs 2054068500 @default.
• W2054068500 citedByCount "12" @default.
• W2054068500 countsByYear W20540685002015 @default.
• W2054068500 countsByYear W20540685002017 @default.
• W2054068500 countsByYear W20540685002018 @default.
• W2054068500 countsByYear W20540685002021 @default.
• W2054068500 countsByYear W20540685002022 @default.
• W2054068500 crossrefType "journal-article" @default.
• W2054068500 hasAuthorship W2054068500A5000302734 @default.
• W2054068500 hasAuthorship W2054068500A5017620945 @default.
• W2054068500 hasAuthorship W2054068500A5023437328 @default.
• W2054068500 hasAuthorship W2054068500A5048765188 @default.
• W2054068500 hasAuthorship W2054068500A5052549091 @default.
• W2054068500 hasAuthorship W2054068500A5060346162 @default.
• W2054068500 hasAuthorship W2054068500A5083662293 @default.
• W2054068500 hasBestOaLocation W20540685001 @default.
• W2054068500 hasConcept C101335993 @default.
• W2054068500 hasConcept C112705442 @default.
• W2054068500 hasConcept C11432220 @default.
• W2054068500 hasConcept C147789679 @default.
• W2054068500 hasConcept C155672457 @default.
• W2054068500 hasConcept C15920480 @default.
• W2054068500 hasConcept C16005928 @default.
• W2054068500 hasConcept C171250308 @default.
• W2054068500 hasConcept C178790620 @default.
• W2054068500 hasConcept C179998833 @default.
• W2054068500 hasConcept C181389837 @default.
• W2054068500 hasConcept C185592680 @default.
• W2054068500 hasConcept C187530423 @default.
• W2054068500 hasConcept C192562407 @default.
• W2054068500 hasConcept C2777071850 @default.
• W2054068500 hasConcept C2779548794 @default.
• W2054068500 hasConcept C2780165375 @default.
• W2054068500 hasConcept C2780306666 @default.
• W2054068500 hasConcept C43617362 @default.
• W2054068500 hasConcept C521977710 @default.
• W2054068500 hasConcept C55493867 @default.
• W2054068500 hasConcept C58226133 @default.
• W2054068500 hasConcept C71924100 @default.
• W2054068500 hasConcept C86181022 @default.
• W2054068500 hasConcept C98274493 @default.
• W2054068500 hasConceptScore W2054068500C101335993 @default.
• W2054068500 hasConceptScore W2054068500C112705442 @default.
• W2054068500 hasConceptScore W2054068500C11432220 @default.
• W2054068500 hasConceptScore W2054068500C147789679 @default.
• W2054068500 hasConceptScore W2054068500C155672457 @default.
• W2054068500 hasConceptScore W2054068500C15920480 @default.
• W2054068500 hasConceptScore W2054068500C16005928 @default.

• next