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• W2054081736 endingPage "371" @default.
• W2054081736 startingPage "363" @default.
• W2054081736 abstract "The mechanisms by which phospholipase C from Clostridium perfringens stimulates release of arachidonic acid (AA) in cultured intestinal epithelial cells (INT-407) were investigated. INT-407 cells were first allowed to incorporate 14C-labeled AA into their phospholipids; the labeled cells were then exposed to phospholipase C, and the release of free l4C-AA was determined. Phospholipase C caused a rapid (3 min) intracellular rise of free l4C-AA, followed by a considerable, dose- and time-dependent release of l4C-AA into the extracellular medium. For comparison, the calcium ionophore A23187 also caused a rapid mobilization of free 14C-AA, but a much lower extracellular 14C-AA release than phospholipase C during longer (1 h) incubation. The 14C-AA release was accompanied by a degradation of l4C-myo-inositol-labeled phosphatidylinositols and was reduced by the protein kinase C inhibitor l-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7). Both phospholipase C- and A23187-stimulated 14C-AA release was associated with degradation of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol and was reduced by nor-dihydroguaiaretic acid and 4-bromophenacyl bromide, two known phospholipase A2 inhibitors. In addition, the 14C-AA release was reduced by the calmodulin inhibitors trifluoperazine, compound 48/80, and A'-(6-aminohexyl)-5-chloro-l-naphthalene-sulfonamide (W-7). These findings indicate that phospholipase C from C. perfringens stimulates phospholipase A2-mediated AA release from human intestinal epithelial cells and suggest that this stimulation is brought about via processes involving phosphatidylinositol breakdown and activation of calmodulin and protein kinase C. It is possible that this phospholipase C-evoked AA release may contribute to the mucosal pathologic condition in diseases with altered intestinal microbial flora." @default.
• W2054081736 created "2016-06-24" @default.
• W2054081736 creator A5034178431 @default.
• W2054081736 creator A5041296160 @default.
• W2054081736 date "1990-01-01" @default.
• W2054081736 modified "2023-09-27" @default.
• W2054081736 title "Phospholipase C from Clostridium perfringens Stimulates Phospholipase A₂-Mediated Arachidonic Acid Release in Cultured Intestinal Epithelial Cells (INT 407)" @default.
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• W2054081736 doi "https://doi.org/10.3109/00365529009095500" @default.
• W2054081736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2110684" @default.
• W2054081736 hasPublicationYear "1990" @default.
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