Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054086856> ?p ?o ?g. }
- W2054086856 endingPage "554" @default.
- W2054086856 startingPage "544" @default.
- W2054086856 abstract "The Na(+)/Ca(2+) exchanger (NCX) is a bi-directional regulator of cytosolic Ca(2+), causing Ca(2+) efflux in forward-mode and Ca(2+) influx in reverse-mode. We hypothesized that reverse-mode NCX is a means of Ca(2+) entry in rat aorta (RA) and vena cava (RVC). NCX protein in RA and RVC was confirmed by immunoprecipitation. To assess NCX function, isometric contraction and intracellular Ca(2+) was measured in RA and RVC rings in response to low extracellular Na(+), endothelin-1 (ET-1), and KCl, in the presence or absence of the NCX antagonist KB-R7943. In RVC, low extracellular Na(+) caused vasoconstriction and an increase in intracellular Ca(2+) that was attenuated by 10μM KB-R7943. KB-R7943 (10 μM) attenuated maximal contraction to ET-1 in RVC (53 ± 9% of control), but not RA (91±1% of control). KB-R7943 (10 μM) reduced the maximal contraction to KCl in RA (48 ± 5%) and nearly abolished it in RVC (9 ± 2%), suggesting that voltage-dependent Ca(2+) influx may be inhibited by KB-R7943 as well. However, the L-type Ca(2+) channel inhibitor nifedipine (1 μM) did not alter ET-1-induced contraction. Our findings suggest that reverse-mode NCX is an important mechanism of Ca(2+) influx in RVC but not RA, especially during ET-1-induced contraction. Also, the effects of KB-R7943 on ET-1-induced contraction of RA and RVC are predominantly mediated by reverse-mode NCX inhibition and not due to off-target inhibition of Ca(2+) channels." @default.
- W2054086856 created "2016-06-24" @default.
- W2054086856 creator A5036076411 @default.
- W2054086856 creator A5039257890 @default.
- W2054086856 creator A5088536388 @default.
- W2054086856 date "2012-12-01" @default.
- W2054086856 modified "2023-10-14" @default.
- W2054086856 title "Reverse-mode Na+/Ca2+ exchange is an important mediator of venous contraction" @default.
- W2054086856 cites W1888944045 @default.
- W2054086856 cites W1944016236 @default.
- W2054086856 cites W1980423569 @default.
- W2054086856 cites W1982420826 @default.
- W2054086856 cites W1995512256 @default.
- W2054086856 cites W2014790415 @default.
- W2054086856 cites W2028685332 @default.
- W2054086856 cites W2030049845 @default.
- W2054086856 cites W2039594558 @default.
- W2054086856 cites W2040526223 @default.
- W2054086856 cites W2050358509 @default.
- W2054086856 cites W2050902176 @default.
- W2054086856 cites W2051829294 @default.
- W2054086856 cites W2055003144 @default.
- W2054086856 cites W2055837976 @default.
- W2054086856 cites W2058549361 @default.
- W2054086856 cites W2058778390 @default.
- W2054086856 cites W2063961981 @default.
- W2054086856 cites W2069465345 @default.
- W2054086856 cites W2071045330 @default.
- W2054086856 cites W2083783310 @default.
- W2054086856 cites W2090378790 @default.
- W2054086856 cites W2092734893 @default.
- W2054086856 cites W2097168752 @default.
- W2054086856 cites W2107313119 @default.
- W2054086856 cites W2108143246 @default.
- W2054086856 cites W2110401779 @default.
- W2054086856 cites W2110892172 @default.
- W2054086856 cites W2115884335 @default.
- W2054086856 cites W2116045913 @default.
- W2054086856 cites W2121020585 @default.
- W2054086856 cites W2128801406 @default.
- W2054086856 cites W2138451942 @default.
- W2054086856 cites W2139584200 @default.
- W2054086856 cites W2161434720 @default.
- W2054086856 cites W2169784899 @default.
- W2054086856 cites W2335815721 @default.
- W2054086856 cites W2415277844 @default.
- W2054086856 doi "https://doi.org/10.1016/j.phrs.2012.08.004" @default.
- W2054086856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3502721" @default.
- W2054086856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22974823" @default.
- W2054086856 hasPublicationYear "2012" @default.
- W2054086856 type Work @default.
- W2054086856 sameAs 2054086856 @default.
- W2054086856 citedByCount "16" @default.
- W2054086856 countsByYear W20540868562014 @default.
- W2054086856 countsByYear W20540868562015 @default.
- W2054086856 countsByYear W20540868562016 @default.
- W2054086856 countsByYear W20540868562018 @default.
- W2054086856 countsByYear W20540868562020 @default.
- W2054086856 countsByYear W20540868562021 @default.
- W2054086856 countsByYear W20540868562022 @default.
- W2054086856 countsByYear W20540868562023 @default.
- W2054086856 crossrefType "journal-article" @default.
- W2054086856 hasAuthorship W2054086856A5036076411 @default.
- W2054086856 hasAuthorship W2054086856A5039257890 @default.
- W2054086856 hasAuthorship W2054086856A5088536388 @default.
- W2054086856 hasBestOaLocation W20540868562 @default.
- W2054086856 hasConcept C12554922 @default.
- W2054086856 hasConcept C126322002 @default.
- W2054086856 hasConcept C134018914 @default.
- W2054086856 hasConcept C149601957 @default.
- W2054086856 hasConcept C163415756 @default.
- W2054086856 hasConcept C170493617 @default.
- W2054086856 hasConcept C178790620 @default.
- W2054086856 hasConcept C181199279 @default.
- W2054086856 hasConcept C185592680 @default.
- W2054086856 hasConcept C2777735026 @default.
- W2054086856 hasConcept C2779066535 @default.
- W2054086856 hasConcept C2779961880 @default.
- W2054086856 hasConcept C28406088 @default.
- W2054086856 hasConcept C519063684 @default.
- W2054086856 hasConcept C55493867 @default.
- W2054086856 hasConcept C71924100 @default.
- W2054086856 hasConcept C79879829 @default.
- W2054086856 hasConcept C86803240 @default.
- W2054086856 hasConcept C95444343 @default.
- W2054086856 hasConcept C98539663 @default.
- W2054086856 hasConceptScore W2054086856C12554922 @default.
- W2054086856 hasConceptScore W2054086856C126322002 @default.
- W2054086856 hasConceptScore W2054086856C134018914 @default.
- W2054086856 hasConceptScore W2054086856C149601957 @default.
- W2054086856 hasConceptScore W2054086856C163415756 @default.
- W2054086856 hasConceptScore W2054086856C170493617 @default.
- W2054086856 hasConceptScore W2054086856C178790620 @default.
- W2054086856 hasConceptScore W2054086856C181199279 @default.
- W2054086856 hasConceptScore W2054086856C185592680 @default.
- W2054086856 hasConceptScore W2054086856C2777735026 @default.
- W2054086856 hasConceptScore W2054086856C2779066535 @default.
- W2054086856 hasConceptScore W2054086856C2779961880 @default.