FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054090690> ?p ?o ?g. }

• W2054090690 endingPage "113" @default.
• W2054090690 startingPage "105" @default.
• W2054090690 abstract "Both miRNAs and nitric oxide (NO) play important roles in colonic inflammation and tumorigenesis. Resistance of colonic epithelial cells to apoptosis may contribute to tumor development. We hypothesized that some miRNAs could increase the resistance of colonic cancer cells to nitric oxide-induced apoptotic cell death. Here we show that NO induced apoptosis and stimulated expression of some miRNAs. Loss of p53 not only blocked NO-induced apoptosis but also dramatically inhibited the expression of NO-related miRNAs, such as miR-34, miR-203, and miR-1301. In addition, blockage of p53-dependent miRNAs significantly reduced NO-induced apoptosis. Furthermore, forced expression of these miRNAs rendered HT-29 cells, which are resistant to apoptosis with mutant p53, more sensitive to NO-induced apoptotic cell death. Most interestingly, in a colitis-associated colon cancer mouse model, the level of miRNAs dropped significantly, accompanied by downregulation of p21, which is a key target gene of p53. In human colorectal cancer samples, the expression of miR-34 significantly correlated with the level of inducible nitric oxide synthase (iNOS). We contend that increased NO production may select cells with low levels of p53-dependent miRNAs which contributes to human colonic carcinogenesis and tumor progression." @default.
• W2054090690 created "2016-06-24" @default.
• W2054090690 creator A5019121945 @default.
• W2054090690 creator A5020170135 @default.
• W2054090690 creator A5022410008 @default.
• W2054090690 creator A5025130830 @default.
• W2054090690 creator A5031930453 @default.
• W2054090690 creator A5042617299 @default.
• W2054090690 creator A5058137203 @default.
• W2054090690 date "2015-08-01" @default.
• W2054090690 modified "2023-10-18" @default.
• W2054090690 title "P53-dependent miRNAs mediate nitric oxide-induced apoptosis in colonic carcinogenesis" @default.
• W2054090690 cites W1964896875 @default.
• W2054090690 cites W1967250455 @default.
• W2054090690 cites W1967337834 @default.
• W2054090690 cites W1970431885 @default.
• W2054090690 cites W1975616657 @default.
• W2054090690 cites W1976029219 @default.
• W2054090690 cites W1979031126 @default.
• W2054090690 cites W1979475097 @default.
• W2054090690 cites W1982460960 @default.
• W2054090690 cites W2002050289 @default.
• W2054090690 cites W2006173503 @default.
• W2054090690 cites W2027598316 @default.
• W2054090690 cites W2033234534 @default.
• W2054090690 cites W2035353347 @default.
• W2054090690 cites W2053041957 @default.
• W2054090690 cites W2063905960 @default.
• W2054090690 cites W2065232902 @default.
• W2054090690 cites W2065566217 @default.
• W2054090690 cites W2067708466 @default.
• W2054090690 cites W2074210527 @default.
• W2054090690 cites W2074958911 @default.
• W2054090690 cites W2079062596 @default.
• W2054090690 cites W2082363749 @default.
• W2054090690 cites W2082654577 @default.
• W2054090690 cites W2096268559 @default.
• W2054090690 cites W2099439420 @default.
• W2054090690 cites W2111547058 @default.
• W2054090690 cites W2124076790 @default.
• W2054090690 cites W2124488916 @default.
• W2054090690 cites W2125690417 @default.
• W2054090690 cites W2136605121 @default.
• W2054090690 cites W2147057201 @default.
• W2054090690 cites W2147708722 @default.
• W2054090690 cites W2147807172 @default.
• W2054090690 cites W2155725240 @default.
• W2054090690 doi "https://doi.org/10.1016/j.freeradbiomed.2015.04.016" @default.
• W2054090690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25912478" @default.
• W2054090690 hasPublicationYear "2015" @default.
• W2054090690 type Work @default.
• W2054090690 sameAs 2054090690 @default.
• W2054090690 citedByCount "23" @default.
• W2054090690 countsByYear W20540906902016 @default.
• W2054090690 countsByYear W20540906902017 @default.
• W2054090690 countsByYear W20540906902018 @default.
• W2054090690 countsByYear W20540906902019 @default.
• W2054090690 countsByYear W20540906902020 @default.
• W2054090690 countsByYear W20540906902021 @default.
• W2054090690 countsByYear W20540906902022 @default.
• W2054090690 countsByYear W20540906902023 @default.
• W2054090690 crossrefType "journal-article" @default.
• W2054090690 hasAuthorship W2054090690A5019121945 @default.
• W2054090690 hasAuthorship W2054090690A5020170135 @default.
• W2054090690 hasAuthorship W2054090690A5022410008 @default.
• W2054090690 hasAuthorship W2054090690A5025130830 @default.
• W2054090690 hasAuthorship W2054090690A5031930453 @default.
• W2054090690 hasAuthorship W2054090690A5042617299 @default.
• W2054090690 hasAuthorship W2054090690A5058137203 @default.
• W2054090690 hasConcept C104317684 @default.
• W2054090690 hasConcept C121608353 @default.
• W2054090690 hasConcept C127561419 @default.
• W2054090690 hasConcept C134018914 @default.
• W2054090690 hasConcept C145059251 @default.
• W2054090690 hasConcept C185592680 @default.
• W2054090690 hasConcept C190283241 @default.
• W2054090690 hasConcept C203014093 @default.
• W2054090690 hasConcept C2776914184 @default.
• W2054090690 hasConcept C2777622882 @default.
• W2054090690 hasConcept C31573885 @default.
• W2054090690 hasConcept C502942594 @default.
• W2054090690 hasConcept C519581460 @default.
• W2054090690 hasConcept C526805850 @default.
• W2054090690 hasConcept C54355233 @default.
• W2054090690 hasConcept C55493867 @default.
• W2054090690 hasConcept C555283112 @default.
• W2054090690 hasConcept C86803240 @default.
• W2054090690 hasConcept C95444343 @default.
• W2054090690 hasConceptScore W2054090690C104317684 @default.
• W2054090690 hasConceptScore W2054090690C121608353 @default.
• W2054090690 hasConceptScore W2054090690C127561419 @default.
• W2054090690 hasConceptScore W2054090690C134018914 @default.
• W2054090690 hasConceptScore W2054090690C145059251 @default.
• W2054090690 hasConceptScore W2054090690C185592680 @default.
• W2054090690 hasConceptScore W2054090690C190283241 @default.
• W2054090690 hasConceptScore W2054090690C203014093 @default.
• W2054090690 hasConceptScore W2054090690C2776914184 @default.
• W2054090690 hasConceptScore W2054090690C2777622882 @default.

• next