FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054093934> ?p ?o ?g. }

• W2054093934 endingPage "224" @default.
• W2054093934 startingPage "217" @default.
• W2054093934 abstract "The anxiolytic effects of the neuroactive steroid, 3 alpha-OH-5 beta-pregnan-20-one (pregnanolone), were determined after injection into the dorsal hippocampus or lateral septum in adult male rats. An increase in the proportion of time spent on the open arms of the elevated plus-maze was found after 2.5 and 5 micrograms of pregnanolone in the hippocampus, but not in the lateral septum. Intrahippocampal injection of 2.5 micrograms of the 3 beta-epimer of pregnanolone did not affect behavior in the plus-maze; a higher dose of 5 micrograms produced an anxiogenic effect. In the shock-probe burying test latency to burying behavior was increased by intrahippocampal or intraseptal injection of 2.5 and 5 micrograms of pregnanolone; the duration of burying behavior was decreased by 0.5, 2.5 and 5 micrograms of pregnanolone injection in the dorsal hippocampus or lateral septum. The number of contacts with the shock probe was not affected by any dose of pregnanolone in either intracranial site of injection. The anxiolytic effects of intrahippocampal or intraseptal injection of pregnanolone were blocked by intracranial pretreatment with 20 ng of picrotoxin, but not by microinjection of 5 micrograms of flumazenil or 200 ng of PK 11195. Thus, inhibition of the hippocampus, mediated by the pregnanolone's action at the GABAA receptor, produces a general anxiolytic effect. However, similar inhibition in the lateral septum attenuates active avoidance of anxiogenic stimuli (i.e., decreased burying behavior), but not passive avoidance of aversive stimuli (i.e., exploration of open arms of the plus-maze and number of shocks in the probe burying test)." @default.
• W2054093934 created "2016-06-24" @default.
• W2054093934 creator A5000764337 @default.
• W2054093934 creator A5002867975 @default.
• W2054093934 creator A5045011878 @default.
• W2054093934 creator A5069401311 @default.
• W2054093934 creator A5070473000 @default.
• W2054093934 date "1999-12-01" @default.
• W2054093934 modified "2023-10-13" @default.
• W2054093934 title "Anxiolytic effects of the neuroactive steroid pregnanolone (3α-OH-5β-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum" @default.
• W2054093934 cites W1771372085 @default.
• W2054093934 cites W1963939779 @default.
• W2054093934 cites W1964151597 @default.
• W2054093934 cites W1968427184 @default.
• W2054093934 cites W1970815698 @default.
• W2054093934 cites W1972669181 @default.
• W2054093934 cites W1973309598 @default.
• W2054093934 cites W1975649039 @default.
• W2054093934 cites W1978803611 @default.
• W2054093934 cites W1982627216 @default.
• W2054093934 cites W1990804897 @default.
• W2054093934 cites W1993427526 @default.
• W2054093934 cites W1994164430 @default.
• W2054093934 cites W1994924064 @default.
• W2054093934 cites W1995130008 @default.
• W2054093934 cites W1997437960 @default.
• W2054093934 cites W1997588362 @default.
• W2054093934 cites W2006949255 @default.
• W2054093934 cites W2012767314 @default.
• W2054093934 cites W2014371004 @default.
• W2054093934 cites W2015275360 @default.
• W2054093934 cites W2024015272 @default.
• W2054093934 cites W2024344189 @default.
• W2054093934 cites W2026320973 @default.
• W2054093934 cites W2032709032 @default.
• W2054093934 cites W2036047888 @default.
• W2054093934 cites W2041561931 @default.
• W2054093934 cites W2056224205 @default.
• W2054093934 cites W2058762208 @default.
• W2054093934 cites W2066613885 @default.
• W2054093934 cites W2067673728 @default.
• W2054093934 cites W2076787408 @default.
• W2054093934 cites W2083447043 @default.
• W2054093934 cites W2083756752 @default.
• W2054093934 cites W2088226858 @default.
• W2054093934 cites W2089693821 @default.
• W2054093934 cites W2093335845 @default.
• W2054093934 cites W2115583232 @default.
• W2054093934 cites W2123166498 @default.
• W2054093934 cites W2124151108 @default.
• W2054093934 cites W2127137403 @default.
• W2054093934 cites W2135681160 @default.
• W2054093934 cites W2147143888 @default.
• W2054093934 cites W4236974483 @default.
• W2054093934 cites W4242380188 @default.
• W2054093934 doi "https://doi.org/10.1016/s0006-8993(99)02150-2" @default.
• W2054093934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10629767" @default.
• W2054093934 hasPublicationYear "1999" @default.
• W2054093934 type Work @default.
• W2054093934 sameAs 2054093934 @default.
• W2054093934 citedByCount "128" @default.
• W2054093934 countsByYear W20540939342012 @default.
• W2054093934 countsByYear W20540939342013 @default.
• W2054093934 countsByYear W20540939342014 @default.
• W2054093934 countsByYear W20540939342015 @default.
• W2054093934 countsByYear W20540939342016 @default.
• W2054093934 countsByYear W20540939342017 @default.
• W2054093934 countsByYear W20540939342019 @default.
• W2054093934 countsByYear W20540939342020 @default.
• W2054093934 countsByYear W20540939342021 @default.
• W2054093934 countsByYear W20540939342022 @default.
• W2054093934 crossrefType "journal-article" @default.
• W2054093934 hasAuthorship W2054093934A5000764337 @default.
• W2054093934 hasAuthorship W2054093934A5002867975 @default.
• W2054093934 hasAuthorship W2054093934A5045011878 @default.
• W2054093934 hasAuthorship W2054093934A5069401311 @default.
• W2054093934 hasAuthorship W2054093934A5070473000 @default.
• W2054093934 hasConcept C126322002 @default.
• W2054093934 hasConcept C134018914 @default.
• W2054093934 hasConcept C168258287 @default.
• W2054093934 hasConcept C170493617 @default.
• W2054093934 hasConcept C185592680 @default.
• W2054093934 hasConcept C205044023 @default.
• W2054093934 hasConcept C2776801781 @default.
• W2054093934 hasConcept C2777765862 @default.
• W2054093934 hasConcept C2778338918 @default.
• W2054093934 hasConcept C2778409475 @default.
• W2054093934 hasConcept C2780957381 @default.
• W2054093934 hasConcept C2781161787 @default.
• W2054093934 hasConcept C44796713 @default.
• W2054093934 hasConcept C62525196 @default.
• W2054093934 hasConcept C71924100 @default.
• W2054093934 hasConceptScore W2054093934C126322002 @default.
• W2054093934 hasConceptScore W2054093934C134018914 @default.
• W2054093934 hasConceptScore W2054093934C168258287 @default.
• W2054093934 hasConceptScore W2054093934C170493617 @default.
• W2054093934 hasConceptScore W2054093934C185592680 @default.
• W2054093934 hasConceptScore W2054093934C205044023 @default.

• next