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• W2054093997 startingPage "901" @default.
• W2054093997 abstract "We are studying how axons branch in vivo. Individual cortical neurons send axons to both the spinal cord and the basilar pons. Here we show that the corticopontine projection develops by an interstitial budding of collaterals from parent axons rather than a reported mechanism of axon branching, growth cone bifurcation. This mechanism is used regardless of whether the parent axon's postpontine segment, which forms the corticospinal projection, is permanent (motor cortex) or transient (visual cortex). Budding occurs days after the parent axons grow spinally past the pons, accounting for the “waiting period” reported in this system in contrast to an alternative explanation that the growth cones pause outside of their target. Timing and location of pontine collateral budding vary with cortical origin of the parent axon and are correlated with the temporal ordering of axon arrival." @default.
• W2054093997 created "2016-06-24" @default.
• W2054093997 creator A5012926933 @default.
• W2054093997 creator A5058321251 @default.
• W2054093997 date "1988-12-01" @default.
• W2054093997 modified "2023-10-05" @default.
• W2054093997 title "Cortical axons branch to multiple subcortical targets by interstitial axon budding: Implications for target recognition and “waiting periods”" @default.
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• W2054093997 doi "https://doi.org/10.1016/0896-6273(88)90147-x" @default.
• W2054093997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3272157" @default.
• W2054093997 hasPublicationYear "1988" @default.
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