FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054100919> ?p ?o ?g. }

• W2054100919 endingPage "41" @default.
• W2054100919 startingPage "34" @default.
• W2054100919 abstract "Immune responses are markedly depressed very early after the onset of hemorrhage. Furthermore, endothelial cell dysfunction occurs after trauma-hemorrhage and may contribute to alterations in immune function. Recent studies have shown that administration of L-arginine restores the depressed organ blood flow, probably because of the provision of substrate for constitutive nitric oxide synthase. It remains unknown, however, whether administration of L-arginine would have any salutary effect on the depressed macrophage function after trauma-hemorrhage.Male rats underwent midline laparotomy (i.e., trauma was induced). After this, the animals were bled to and maintained at a mean blood pressure of 40 mm Hg until 40% of the maximum shed blood volume was returned in the form of lactated Ringer's solution. Sham-operated rats underwent both femoral artery cannulation and ligation, but these animals were neither bled nor resuscitated. Hemorrhaged rats were then resuscitated with lactated Ringer's solution, receiving four times the maximum shed blood volume over 1 hour. During resuscitation, one group received 300 mg/kg L-arginine and the other group received saline (vehicle) intravenously. At 4 hours after resuscitation, splenic and peritoneal macrophage interleukin (IL)-1beta and IL-6 release as well as plasma IL-6 were measured.Splenic and peritoneal macrophage IL-1beta and IL-6 release was significantly decreased in trauma-hemorrhage vehicle-treated rats. Administration of L-arginine after trauma-hemorrhage, however, improved splenic and peritoneal macrophage IL-1beta and IL-6 release. Moreover, the up-regulated plasma levels of IL-6 were attenuated by L-arginine administration.L-Arginine administration after trauma-hemorrhage significantly improves the depressed macrophage function, presumably by decreasing the increased plasma IL-6 levels and improving organ blood flow. Early enhancement of the depressed constitutive nitric oxide synthase activity by provision of L-arginine after trauma-hemorrhage, therefore, represents a novel and safe approach for improving the depressed immune function and decreasing plasma IL-6 levels under such conditions." @default.
• W2054100919 created "2016-06-24" @default.
• W2054100919 creator A5003446329 @default.
• W2054100919 creator A5022512059 @default.
• W2054100919 creator A5065013461 @default.
• W2054100919 creator A5066761803 @default.
• W2054100919 creator A5084834018 @default.
• W2054100919 creator A5085171919 @default.
• W2054100919 date "1999-01-01" @default.
• W2054100919 modified "2023-09-25" @default.
• W2054100919 title "L-Arginine" @default.
• W2054100919 cites W122947453 @default.
• W2054100919 cites W1967919909 @default.
• W2054100919 cites W1973647960 @default.
• W2054100919 cites W1991780618 @default.
• W2054100919 cites W1997507148 @default.
• W2054100919 cites W2002328221 @default.
• W2054100919 cites W2007825400 @default.
• W2054100919 cites W2015225665 @default.
• W2054100919 cites W2015847308 @default.
• W2054100919 cites W2031356516 @default.
• W2054100919 cites W2033703685 @default.
• W2054100919 cites W2040588600 @default.
• W2054100919 cites W2044847181 @default.
• W2054100919 cites W2045074773 @default.
• W2054100919 cites W2046739059 @default.
• W2054100919 cites W2046815219 @default.
• W2054100919 cites W2047326953 @default.
• W2054100919 cites W2061897451 @default.
• W2054100919 cites W2062299788 @default.
• W2054100919 cites W2070816199 @default.
• W2054100919 cites W2093799856 @default.
• W2054100919 cites W2108690804 @default.
• W2054100919 cites W2142585662 @default.
• W2054100919 cites W2263205512 @default.
• W2054100919 cites W2411780263 @default.
• W2054100919 cites W2412427424 @default.
• W2054100919 cites W4241073654 @default.
• W2054100919 cites W45146937 @default.
• W2054100919 doi "https://doi.org/10.1097/00005373-199901000-00006" @default.
• W2054100919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9932681" @default.
• W2054100919 hasPublicationYear "1999" @default.
• W2054100919 type Work @default.
• W2054100919 sameAs 2054100919 @default.
• W2054100919 citedByCount "51" @default.
• W2054100919 countsByYear W20541009192012 @default.
• W2054100919 countsByYear W20541009192014 @default.
• W2054100919 countsByYear W20541009192015 @default.
• W2054100919 countsByYear W20541009192016 @default.
• W2054100919 countsByYear W20541009192019 @default.
• W2054100919 countsByYear W20541009192020 @default.
• W2054100919 countsByYear W20541009192021 @default.
• W2054100919 crossrefType "journal-article" @default.
• W2054100919 hasAuthorship W2054100919A5003446329 @default.
• W2054100919 hasAuthorship W2054100919A5022512059 @default.
• W2054100919 hasAuthorship W2054100919A5065013461 @default.
• W2054100919 hasAuthorship W2054100919A5066761803 @default.
• W2054100919 hasAuthorship W2054100919A5084834018 @default.
• W2054100919 hasAuthorship W2054100919A5085171919 @default.
• W2054100919 hasConcept C126322002 @default.
• W2054100919 hasConcept C141071460 @default.
• W2054100919 hasConcept C185592680 @default.
• W2054100919 hasConcept C202751555 @default.
• W2054100919 hasConcept C203014093 @default.
• W2054100919 hasConcept C2777397205 @default.
• W2054100919 hasConcept C2777468819 @default.
• W2054100919 hasConcept C2777622882 @default.
• W2054100919 hasConcept C2778165595 @default.
• W2054100919 hasConcept C2779244956 @default.
• W2054100919 hasConcept C2779723990 @default.
• W2054100919 hasConcept C2780778865 @default.
• W2054100919 hasConcept C42219234 @default.
• W2054100919 hasConcept C515207424 @default.
• W2054100919 hasConcept C519581460 @default.
• W2054100919 hasConcept C55493867 @default.
• W2054100919 hasConcept C71924100 @default.
• W2054100919 hasConcept C8891405 @default.
• W2054100919 hasConceptScore W2054100919C126322002 @default.
• W2054100919 hasConceptScore W2054100919C141071460 @default.
• W2054100919 hasConceptScore W2054100919C185592680 @default.
• W2054100919 hasConceptScore W2054100919C202751555 @default.
• W2054100919 hasConceptScore W2054100919C203014093 @default.
• W2054100919 hasConceptScore W2054100919C2777397205 @default.
• W2054100919 hasConceptScore W2054100919C2777468819 @default.
• W2054100919 hasConceptScore W2054100919C2777622882 @default.
• W2054100919 hasConceptScore W2054100919C2778165595 @default.
• W2054100919 hasConceptScore W2054100919C2779244956 @default.
• W2054100919 hasConceptScore W2054100919C2779723990 @default.
• W2054100919 hasConceptScore W2054100919C2780778865 @default.
• W2054100919 hasConceptScore W2054100919C42219234 @default.
• W2054100919 hasConceptScore W2054100919C515207424 @default.
• W2054100919 hasConceptScore W2054100919C519581460 @default.
• W2054100919 hasConceptScore W2054100919C55493867 @default.
• W2054100919 hasConceptScore W2054100919C71924100 @default.
• W2054100919 hasConceptScore W2054100919C8891405 @default.
• W2054100919 hasIssue "1" @default.
• W2054100919 hasLocation W20541009191 @default.
• W2054100919 hasLocation W20541009192 @default.

• next