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- W2054102092 abstract "A bioassay is described here which is a rapid, accurate and highly sensitive method for measuring serum concentrations of cycloguanil, the active metabolite of proguanil. The method was based on microscopic observations of the inhibition of a cycloguanil sensitive isolate of Plasmodium falciparum (FCQ-27) grown in vitro in the presence of serum containing cycloguanil. The accuracy of the bioassay was comparable to that of a high performance liquid Chromatographie (HPLC) method at concentrations above 5 ng ml−1 (the detection limit of the physicochemical procedure), and could measure cycloguanil concentrations as low as 0.3 ng ml−1 without the need for expensive analytical equipment. The bioassay was used to determine the steady-state serum concentrations of cycloguanil in six healthy male volunteers after daily administration of two tablets of Paludrine® (200 mg proguanil hydrochloride). Cycloguanil had a biphasic elimination with mean elimination half-lives (t12) of 13.5 ± 2.7 h (Sps.d) and 20.3 ± 1.6 h from 12 to 24 h and 24 to 72 h, respectively, following the final drug administration" @default.
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- W2054102092 date "1988-07-01" @default.
- W2054102092 modified "2023-09-25" @default.
- W2054102092 title "A sensitive bioassay for serum cycloguanil using Plasmodium falciparumin vitro" @default.
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- W2054102092 doi "https://doi.org/10.1016/0020-7519(88)90094-x" @default.
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