FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054109317> ?p ?o ?g. }

• W2054109317 endingPage "e0121957" @default.
• W2054109317 startingPage "e0121957" @default.
• W2054109317 abstract "Chondroitin/dermatan sulfate (CS/DS) proteoglycans consist of unbranched sulfated polysaccharide chains of repeating GalNAc-GlcA/IdoA disaccharide units, attached to serine residues on specific proteins. The CS/DS proteoglycans are abundant in the extracellular matrix where they have essential functions in tissue development and homeostasis. In this report a phylogenetic analysis of vertebrate genes coding for the enzymes that modify CS/DS is presented. We identify single orthologous genes in the zebrafish genome for the sulfotransferases chst7, chst11, chst13, chst14, chst15 and ust and the epimerase dse. In contrast, two copies were found for mammalian sulfotransferases CHST3 and CHST12 and the epimerase DSEL, named chst3a and chst3b, chst12a and chst12b, dsela and dselb, respectively. Expression of CS/DS modification enzymes is spatially and temporally regulated with a large variation between different genes. We found that CS/DS 4-O-sulfotransferases and 6-O-sulfotransferases as well as CS/DS epimerases show a strong and partly overlapping expression, whereas the expression is restricted for enzymes with ability to synthesize di-sulfated disaccharides. A structural analysis further showed that CS/DS sulfation increases during embryonic development mainly due to synthesis of 4-O-sulfated GalNAc while the proportion of 6-O-sulfated GalNAc increases in later developmental stages. Di-sulfated GalNAc synthesized by Chst15 and 2-O-sulfated GlcA/IdoA synthesized by Ust are rare, in accordance with the restricted expression of these enzymes. We also compared CS/DS composition with that of heparan sulfate (HS). Notably, CS/DS biosynthesis in early zebrafish development is more dynamic than HS biosynthesis. Furthermore, HS contains disaccharides with more than one sulfate group, which are virtually absent in CS/DS." @default.
• W2054109317 created "2016-06-24" @default.
• W2054109317 creator A5010140010 @default.
• W2054109317 creator A5035981492 @default.
• W2054109317 creator A5040775381 @default.
• W2054109317 creator A5052206889 @default.
• W2054109317 creator A5073946959 @default.
• W2054109317 creator A5075495308 @default.
• W2054109317 creator A5090710163 @default.
• W2054109317 date "2015-03-20" @default.
• W2054109317 modified "2023-09-25" @default.
• W2054109317 title "Chondroitin / Dermatan Sulfate Modification Enzymes in Zebrafish Development" @default.
• W2054109317 cites W134050142 @default.
• W2054109317 cites W1491258380 @default.
• W2054109317 cites W1494793657 @default.
• W2054109317 cites W1519298936 @default.
• W2054109317 cites W1802337640 @default.
• W2054109317 cites W1979806459 @default.
• W2054109317 cites W1985163729 @default.
• W2054109317 cites W1988682653 @default.
• W2054109317 cites W1989303090 @default.
• W2054109317 cites W1989843183 @default.
• W2054109317 cites W1992913540 @default.
• W2054109317 cites W1998312331 @default.
• W2054109317 cites W2005681990 @default.
• W2054109317 cites W2010199873 @default.
• W2054109317 cites W2014173198 @default.
• W2054109317 cites W2023990383 @default.
• W2054109317 cites W2027436484 @default.
• W2054109317 cites W2040709432 @default.
• W2054109317 cites W2041768758 @default.
• W2054109317 cites W2046300828 @default.
• W2054109317 cites W2049556477 @default.
• W2054109317 cites W2052690951 @default.
• W2054109317 cites W2053188090 @default.
• W2054109317 cites W2056088021 @default.
• W2054109317 cites W2058877705 @default.
• W2054109317 cites W2066747545 @default.
• W2054109317 cites W2068650843 @default.
• W2054109317 cites W2070308395 @default.
• W2054109317 cites W2073170672 @default.
• W2054109317 cites W2074987771 @default.
• W2054109317 cites W2078474557 @default.
• W2054109317 cites W2083719671 @default.
• W2054109317 cites W2092902908 @default.
• W2054109317 cites W2099087646 @default.
• W2054109317 cites W2120471129 @default.
• W2054109317 cites W2123422430 @default.
• W2054109317 cites W2125349610 @default.
• W2054109317 cites W2126867710 @default.
• W2054109317 cites W2127322768 @default.
• W2054109317 cites W2128944904 @default.
• W2054109317 cites W2133789497 @default.
• W2054109317 cites W2138283511 @default.
• W2054109317 cites W2138314785 @default.
• W2054109317 cites W2141046132 @default.
• W2054109317 cites W2150230173 @default.
• W2054109317 cites W2150297520 @default.
• W2054109317 cites W2151789787 @default.
• W2054109317 cites W2156369645 @default.
• W2054109317 cites W2159046800 @default.
• W2054109317 cites W2159644611 @default.
• W2054109317 cites W2160835895 @default.
• W2054109317 cites W2168107590 @default.
• W2054109317 cites W4210290733 @default.
• W2054109317 doi "https://doi.org/10.1371/journal.pone.0121957" @default.
• W2054109317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4368567" @default.
• W2054109317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25793894" @default.
• W2054109317 hasPublicationYear "2015" @default.
• W2054109317 type Work @default.
• W2054109317 sameAs 2054109317 @default.
• W2054109317 citedByCount "17" @default.
• W2054109317 countsByYear W20541093172017 @default.
• W2054109317 countsByYear W20541093172018 @default.
• W2054109317 countsByYear W20541093172019 @default.
• W2054109317 countsByYear W20541093172020 @default.
• W2054109317 countsByYear W20541093172021 @default.
• W2054109317 countsByYear W20541093172022 @default.
• W2054109317 countsByYear W20541093172023 @default.
• W2054109317 crossrefType "journal-article" @default.
• W2054109317 hasAuthorship W2054109317A5010140010 @default.
• W2054109317 hasAuthorship W2054109317A5035981492 @default.
• W2054109317 hasAuthorship W2054109317A5040775381 @default.
• W2054109317 hasAuthorship W2054109317A5052206889 @default.
• W2054109317 hasAuthorship W2054109317A5073946959 @default.
• W2054109317 hasAuthorship W2054109317A5075495308 @default.
• W2054109317 hasAuthorship W2054109317A5090710163 @default.
• W2054109317 hasBestOaLocation W20541093171 @default.
• W2054109317 hasConcept C104317684 @default.
• W2054109317 hasConcept C153074725 @default.
• W2054109317 hasConcept C155138218 @default.
• W2054109317 hasConcept C181199279 @default.
• W2054109317 hasConcept C185592680 @default.
• W2054109317 hasConcept C2775904581 @default.
• W2054109317 hasConcept C2776735749 @default.
• W2054109317 hasConcept C2776878037 @default.
• W2054109317 hasConcept C2778041096 @default.
• W2054109317 hasConcept C2778066728 @default.

• next