Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054121489> ?p ?o ?g. }
- W2054121489 endingPage "1038" @default.
- W2054121489 startingPage "1037" @default.
- W2054121489 abstract "In a recent study, we investigated the relationship between inclusion body (IB) formation and the activity of the ubiquitin-proteasome system (UPS) in a primary neuron model of Huntington disease. We followed individual neurons over thecourse of days and monitored the level of mutant huntingtin (htt) (which causes Huntington disease), IB formation, UPS function,and neuronal toxicity. The accumulation of UPS substrates and neuronal toxicity increased with increasing levels of proteasomeinhibition. The UPS was more impaired in neurons that subsequently formed IBs than in those that did not; however, after IBsformed, UPS function improved. These findings suggest that IB formation is a protective cellular response mediated in part byincreased degradation of intracellular protein." @default.
- W2054121489 created "2016-06-24" @default.
- W2054121489 creator A5006303593 @default.
- W2054121489 creator A5047461809 @default.
- W2054121489 creator A5064983402 @default.
- W2054121489 date "2009-10-01" @default.
- W2054121489 modified "2023-09-25" @default.
- W2054121489 title "Protein turnover and inclusion body formation" @default.
- W2054121489 doi "https://doi.org/10.4161/auto.5.7.9291" @default.
- W2054121489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2892253" @default.
- W2054121489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19838079" @default.
- W2054121489 hasPublicationYear "2009" @default.
- W2054121489 type Work @default.
- W2054121489 sameAs 2054121489 @default.
- W2054121489 citedByCount "46" @default.
- W2054121489 countsByYear W20541214892012 @default.
- W2054121489 countsByYear W20541214892013 @default.
- W2054121489 countsByYear W20541214892014 @default.
- W2054121489 countsByYear W20541214892015 @default.
- W2054121489 countsByYear W20541214892016 @default.
- W2054121489 countsByYear W20541214892017 @default.
- W2054121489 countsByYear W20541214892018 @default.
- W2054121489 countsByYear W20541214892019 @default.
- W2054121489 countsByYear W20541214892020 @default.
- W2054121489 countsByYear W20541214892021 @default.
- W2054121489 countsByYear W20541214892022 @default.
- W2054121489 countsByYear W20541214892023 @default.
- W2054121489 crossrefType "journal-article" @default.
- W2054121489 hasAuthorship W2054121489A5006303593 @default.
- W2054121489 hasAuthorship W2054121489A5047461809 @default.
- W2054121489 hasAuthorship W2054121489A5064983402 @default.
- W2054121489 hasBestOaLocation W20541214891 @default.
- W2054121489 hasConcept C104317684 @default.
- W2054121489 hasConcept C126322002 @default.
- W2054121489 hasConcept C14036430 @default.
- W2054121489 hasConcept C143065580 @default.
- W2054121489 hasConcept C169760540 @default.
- W2054121489 hasConcept C190283241 @default.
- W2054121489 hasConcept C195580219 @default.
- W2054121489 hasConcept C203522944 @default.
- W2054121489 hasConcept C203750385 @default.
- W2054121489 hasConcept C25602115 @default.
- W2054121489 hasConcept C27740335 @default.
- W2054121489 hasConcept C2776925932 @default.
- W2054121489 hasConcept C2778794669 @default.
- W2054121489 hasConcept C2779134260 @default.
- W2054121489 hasConcept C2779491297 @default.
- W2054121489 hasConcept C2780596555 @default.
- W2054121489 hasConcept C2780647506 @default.
- W2054121489 hasConcept C2781427258 @default.
- W2054121489 hasConcept C2910011555 @default.
- W2054121489 hasConcept C29730261 @default.
- W2054121489 hasConcept C3675279 @default.
- W2054121489 hasConcept C547475151 @default.
- W2054121489 hasConcept C55493867 @default.
- W2054121489 hasConcept C71924100 @default.
- W2054121489 hasConcept C79879829 @default.
- W2054121489 hasConcept C86803240 @default.
- W2054121489 hasConcept C95444343 @default.
- W2054121489 hasConceptScore W2054121489C104317684 @default.
- W2054121489 hasConceptScore W2054121489C126322002 @default.
- W2054121489 hasConceptScore W2054121489C14036430 @default.
- W2054121489 hasConceptScore W2054121489C143065580 @default.
- W2054121489 hasConceptScore W2054121489C169760540 @default.
- W2054121489 hasConceptScore W2054121489C190283241 @default.
- W2054121489 hasConceptScore W2054121489C195580219 @default.
- W2054121489 hasConceptScore W2054121489C203522944 @default.
- W2054121489 hasConceptScore W2054121489C203750385 @default.
- W2054121489 hasConceptScore W2054121489C25602115 @default.
- W2054121489 hasConceptScore W2054121489C27740335 @default.
- W2054121489 hasConceptScore W2054121489C2776925932 @default.
- W2054121489 hasConceptScore W2054121489C2778794669 @default.
- W2054121489 hasConceptScore W2054121489C2779134260 @default.
- W2054121489 hasConceptScore W2054121489C2779491297 @default.
- W2054121489 hasConceptScore W2054121489C2780596555 @default.
- W2054121489 hasConceptScore W2054121489C2780647506 @default.
- W2054121489 hasConceptScore W2054121489C2781427258 @default.
- W2054121489 hasConceptScore W2054121489C2910011555 @default.
- W2054121489 hasConceptScore W2054121489C29730261 @default.
- W2054121489 hasConceptScore W2054121489C3675279 @default.
- W2054121489 hasConceptScore W2054121489C547475151 @default.
- W2054121489 hasConceptScore W2054121489C55493867 @default.
- W2054121489 hasConceptScore W2054121489C71924100 @default.
- W2054121489 hasConceptScore W2054121489C79879829 @default.
- W2054121489 hasConceptScore W2054121489C86803240 @default.
- W2054121489 hasConceptScore W2054121489C95444343 @default.
- W2054121489 hasIssue "7" @default.
- W2054121489 hasLocation W20541214891 @default.
- W2054121489 hasLocation W20541214892 @default.
- W2054121489 hasLocation W20541214893 @default.
- W2054121489 hasLocation W20541214894 @default.
- W2054121489 hasOpenAccess W2054121489 @default.
- W2054121489 hasPrimaryLocation W20541214891 @default.
- W2054121489 hasRelatedWork W1969342645 @default.
- W2054121489 hasRelatedWork W2032730097 @default.
- W2054121489 hasRelatedWork W2048000239 @default.
- W2054121489 hasRelatedWork W2054121489 @default.
- W2054121489 hasRelatedWork W2111567059 @default.