FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054121574> ?p ?o ?g. }

• W2054121574 endingPage "289" @default.
• W2054121574 startingPage "280" @default.
• W2054121574 abstract "Neonatal exposure to estrogenic endocrine disrupting compounds (EDCs) can advance pubertal onset and induce premature anestrous in female rats. It was recently discovered that hypothalamic kisspeptin (KISS) signaling pathways are sexually dimorphic and regulate both the timing of pubertal onset and estrous cyclicity. Thus we hypothesized that disrupted sex specific ontogeny of KISS signaling pathways might be a mechanism underlying these EDC effects. We first established the sex specific development of KISS gene expression, cell number and neural fiber density across peripuberty in the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC), hypothesizing that the sexually dimorphic aspects of KISS signaling would be most vulnerable to EDCs. We next exposed female rats to the phytoestrogen genistein (GEN, 1 or 10 mg/kg bw), estradiol benzoate (EB, 10 μg), or vehicle from post natal day (P) 0-3 via subcutaneous (sc) injection. Animals were sacrificed on either P21, 24, 28, or 33 (n=5-14 per group at each age). Vaginal opening was significantly advanced by EB and the higher dose of GEN compared to control animals and was accompanied by lower numbers of KISS immunoreactive fibers in the AVPV and ARC. Ovarian morphology was also assessed in all age groups for the presence of multiple oocyte follicles (MOFs). The number of MOFs decreased over time in each group, and none were observed in control animals by P24. MOFs were still present, however, in the EB and 10 mg/kg GEN groups beyond P24 indicating a disruption in the timing of ovarian development." @default.
• W2054121574 created "2016-06-24" @default.
• W2054121574 creator A5004110375 @default.
• W2054121574 creator A5056745479 @default.
• W2054121574 creator A5073527138 @default.
• W2054121574 creator A5073787363 @default.
• W2054121574 creator A5079442229 @default.
• W2054121574 creator A5083274986 @default.
• W2054121574 date "2011-04-01" @default.
• W2054121574 modified "2023-10-13" @default.
• W2054121574 title "Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat" @default.
• W2054121574 cites W136599355 @default.
• W2054121574 cites W1656644300 @default.
• W2054121574 cites W1835169213 @default.
• W2054121574 cites W1955310396 @default.
• W2054121574 cites W1967425557 @default.
• W2054121574 cites W1967504860 @default.
• W2054121574 cites W1972520826 @default.
• W2054121574 cites W1975890243 @default.
• W2054121574 cites W1976985571 @default.
• W2054121574 cites W1980881745 @default.
• W2054121574 cites W1981358429 @default.
• W2054121574 cites W1984902037 @default.
• W2054121574 cites W1988736580 @default.
• W2054121574 cites W1998549446 @default.
• W2054121574 cites W1998771264 @default.
• W2054121574 cites W1998983965 @default.
• W2054121574 cites W2004026274 @default.
• W2054121574 cites W2009527950 @default.
• W2054121574 cites W2010855604 @default.
• W2054121574 cites W2014599301 @default.
• W2054121574 cites W2017450677 @default.
• W2054121574 cites W2017769758 @default.
• W2054121574 cites W2022165854 @default.
• W2054121574 cites W2028777780 @default.
• W2054121574 cites W2037435290 @default.
• W2054121574 cites W2039404714 @default.
• W2054121574 cites W2044431633 @default.
• W2054121574 cites W2045690475 @default.
• W2054121574 cites W2050395183 @default.
• W2054121574 cites W2056439165 @default.
• W2054121574 cites W2058683100 @default.
• W2054121574 cites W2062391649 @default.
• W2054121574 cites W2063356932 @default.
• W2054121574 cites W2066627511 @default.
• W2054121574 cites W2067130406 @default.
• W2054121574 cites W2068426167 @default.
• W2054121574 cites W2068757410 @default.
• W2054121574 cites W2072196971 @default.
• W2054121574 cites W2073977177 @default.
• W2054121574 cites W2082763804 @default.
• W2054121574 cites W2085636926 @default.
• W2054121574 cites W2085703900 @default.
• W2054121574 cites W2085869932 @default.
• W2054121574 cites W2091398724 @default.
• W2054121574 cites W2092280065 @default.
• W2054121574 cites W2103933777 @default.
• W2054121574 cites W2107615221 @default.
• W2054121574 cites W2111824942 @default.
• W2054121574 cites W2113305633 @default.
• W2054121574 cites W2113979917 @default.
• W2054121574 cites W2116913923 @default.
• W2054121574 cites W2118750014 @default.
• W2054121574 cites W2121986949 @default.
• W2054121574 cites W2123476163 @default.
• W2054121574 cites W2126929703 @default.
• W2054121574 cites W2142686356 @default.
• W2054121574 cites W2143506157 @default.
• W2054121574 cites W2144727302 @default.
• W2054121574 cites W2154509542 @default.
• W2054121574 cites W2154968546 @default.
• W2054121574 cites W2163467772 @default.
• W2054121574 cites W2163478251 @default.
• W2054121574 cites W2166438602 @default.
• W2054121574 cites W2168887086 @default.
• W2054121574 cites W2169328139 @default.
• W2054121574 cites W2179275055 @default.
• W2054121574 cites W2911273765 @default.
• W2054121574 cites W4234361030 @default.
• W2054121574 cites W4242458759 @default.
• W2054121574 cites W4243490631 @default.
• W2054121574 cites W4251409858 @default.
• W2054121574 doi "https://doi.org/10.1016/j.reprotox.2010.10.002" @default.
• W2054121574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3034101" @default.
• W2054121574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20951797" @default.
• W2054121574 hasPublicationYear "2011" @default.
• W2054121574 type Work @default.
• W2054121574 sameAs 2054121574 @default.
• W2054121574 citedByCount "80" @default.
• W2054121574 countsByYear W20541215742012 @default.
• W2054121574 countsByYear W20541215742013 @default.
• W2054121574 countsByYear W20541215742014 @default.
• W2054121574 countsByYear W20541215742015 @default.
• W2054121574 countsByYear W20541215742016 @default.
• W2054121574 countsByYear W20541215742017 @default.
• W2054121574 countsByYear W20541215742018 @default.
• W2054121574 countsByYear W20541215742019 @default.
• W2054121574 countsByYear W20541215742020 @default.

• next