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- W2054121737 abstract "N-(2,6-dihydroxybenzoyl)-2- and 4-aminobenzoic acids, β- and γ-resorcylimides were prepared, characterized and tested for uncoupling activity. O-acyl (and N-acyl) derivatives of salicylamide, of γ-resorcylamide and of picric acid uncoupled oxidative phosphorylation and were hydrolysed to the parent phenol by rat liver mitochondrial preparations: salicylamide and picric acid, added as such, had no effect on mitochondrial phosphorylation. N-salicyl-anthranilic acid and salicylimide were unique in their powerful uncoupling activity: the corresponding 2,4- and 2,6-dihydroxybenzoyl (β- and γ-resorcyl) derivatives were much less active in this respect. These findings are discussed with respect to physico-chemical determinants of uncoupling activity, the concept of drug latentiation and the anti-inflammatory activity of 4-oxo-benz-1: 3-oxazines (cyclic derivatives of salicylamide)." @default.
- W2054121737 created "2016-06-24" @default.
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- W2054121737 date "1966-09-01" @default.
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- W2054121737 title "Uncoupling of oxidative phosphorylation by some salicylamide derivatives" @default.
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- W2054121737 doi "https://doi.org/10.1016/0006-2952(66)90048-7" @default.
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