FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054123743> ?p ?o ?g. }

• W2054123743 endingPage "516" @default.
• W2054123743 startingPage "511" @default.
• W2054123743 abstract "The development of more effective antituberculosis vaccines would assist in the control of the global problem of infection with Mycobacterium tuberculosis. One recent vaccination strategy is immunization with DNA plasmids encoding individual microbial genes. Using the genes for the M. tuberculosis‐ secreted proteins, MPT64 (23 000 MW) and Ag85B (30 000 MW) as candidate antigens, we previously prepared DNA vaccines and demonstrated their ability to stimulate T‐cell responses and confer protection in a mouse model of aerosol tuberculosis (TB). The protective efficacy of the DNA vaccines was less than that promoted by the current vaccine Mycobacterium bovis bacille Calmette–Guèrin (BCG). To improve the immunogenicity and protective efficacy of these mycobacterial vectors, co‐immunization of a plasmid expressing granulocyte–macrophage colony‐stimulating factor (GM‐CSF) was investigated. Intramuscular immunization with DNA expressing MPT64 or Ag85B and GM‐CSF enhanced the antigen‐specific cellular immune response, with increased proliferative response and production of interferon‐γ (IFN‐γ). The titre of antimycobacterial protein immunoglobulin G (IgG) antibodies was unchanged. Mice immunized with DNA vaccines showed reduced pulmonary bacterial load following an aerosol challenge of M. tuberculosis, but codelivery of the plasmid expressing GM‐CSF did not increase the protective effect. Therefore, despite modifying the cellular immune response to DNA vaccines, GM‐CSF does not improve their protective efficacy at the peak of infection after an aerosol challenge with 100 c.f.u. of M. tuberculosis." @default.
• W2054123743 created "2016-06-24" @default.
• W2054123743 creator A5014239001 @default.
• W2054123743 creator A5063791776 @default.
• W2054123743 creator A5066896896 @default.
• W2054123743 creator A5091305712 @default.
• W2054123743 date "1999-04-01" @default.
• W2054123743 modified "2023-10-16" @default.
• W2054123743 title "Co‐immunization with DNA vaccines expressing granulocyte–macrophage colony‐stimulating factor and mycobacterial secreted proteins enhances T‐cell immunity, but not protective efficacy against <i>Mycobacterium tuberculosis</i>" @default.
• W2054123743 cites W1482024060 @default.
• W2054123743 cites W1485081347 @default.
• W2054123743 cites W1491528461 @default.
• W2054123743 cites W1534291012 @default.
• W2054123743 cites W1578611400 @default.
• W2054123743 cites W1578943666 @default.
• W2054123743 cites W1586542207 @default.
• W2054123743 cites W1586802362 @default.
• W2054123743 cites W1660413876 @default.
• W2054123743 cites W1938118789 @default.
• W2054123743 cites W1963683603 @default.
• W2054123743 cites W1973012987 @default.
• W2054123743 cites W1975045527 @default.
• W2054123743 cites W1993630121 @default.
• W2054123743 cites W1994311508 @default.
• W2054123743 cites W2004604338 @default.
• W2054123743 cites W2004962555 @default.
• W2054123743 cites W2014183131 @default.
• W2054123743 cites W2017873272 @default.
• W2054123743 cites W2019546595 @default.
• W2054123743 cites W2031745415 @default.
• W2054123743 cites W2053951102 @default.
• W2054123743 cites W2062860313 @default.
• W2054123743 cites W2075477269 @default.
• W2054123743 cites W2103887556 @default.
• W2054123743 cites W2135272173 @default.
• W2054123743 cites W2137972315 @default.
• W2054123743 cites W2157605618 @default.
• W2054123743 cites W2157656284 @default.
• W2054123743 cites W2158035277 @default.
• W2054123743 cites W2158204548 @default.
• W2054123743 cites W2165123017 @default.
• W2054123743 cites W2166347165 @default.
• W2054123743 cites W2310845402 @default.
• W2054123743 cites W2344342419 @default.
• W2054123743 doi "https://doi.org/10.1046/j.1365-2567.1999.00703.x" @default.
• W2054123743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2326784" @default.
• W2054123743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10233735" @default.
• W2054123743 hasPublicationYear "1999" @default.
• W2054123743 type Work @default.
• W2054123743 sameAs 2054123743 @default.
• W2054123743 citedByCount "65" @default.
• W2054123743 countsByYear W20541237432012 @default.
• W2054123743 countsByYear W20541237432013 @default.
• W2054123743 countsByYear W20541237432014 @default.
• W2054123743 countsByYear W20541237432015 @default.
• W2054123743 countsByYear W20541237432017 @default.
• W2054123743 countsByYear W20541237432018 @default.
• W2054123743 countsByYear W20541237432020 @default.
• W2054123743 crossrefType "journal-article" @default.
• W2054123743 hasAuthorship W2054123743A5014239001 @default.
• W2054123743 hasAuthorship W2054123743A5063791776 @default.
• W2054123743 hasAuthorship W2054123743A5066896896 @default.
• W2054123743 hasAuthorship W2054123743A5091305712 @default.
• W2054123743 hasBestOaLocation W20541237431 @default.
• W2054123743 hasConcept C104317684 @default.
• W2054123743 hasConcept C142724271 @default.
• W2054123743 hasConcept C147483822 @default.
• W2054123743 hasConcept C159047783 @default.
• W2054123743 hasConcept C167508917 @default.
• W2054123743 hasConcept C203014093 @default.
• W2054123743 hasConcept C22744801 @default.
• W2054123743 hasConcept C2777975735 @default.
• W2054123743 hasConcept C2778497218 @default.
• W2054123743 hasConcept C2779078216 @default.
• W2054123743 hasConcept C2780801004 @default.
• W2054123743 hasConcept C2780868878 @default.
• W2054123743 hasConcept C2781069245 @default.
• W2054123743 hasConcept C55493867 @default.
• W2054123743 hasConcept C71924100 @default.
• W2054123743 hasConcept C86803240 @default.
• W2054123743 hasConcept C8891405 @default.
• W2054123743 hasConcept C89423630 @default.
• W2054123743 hasConceptScore W2054123743C104317684 @default.
• W2054123743 hasConceptScore W2054123743C142724271 @default.
• W2054123743 hasConceptScore W2054123743C147483822 @default.
• W2054123743 hasConceptScore W2054123743C159047783 @default.
• W2054123743 hasConceptScore W2054123743C167508917 @default.
• W2054123743 hasConceptScore W2054123743C203014093 @default.
• W2054123743 hasConceptScore W2054123743C22744801 @default.
• W2054123743 hasConceptScore W2054123743C2777975735 @default.
• W2054123743 hasConceptScore W2054123743C2778497218 @default.
• W2054123743 hasConceptScore W2054123743C2779078216 @default.
• W2054123743 hasConceptScore W2054123743C2780801004 @default.
• W2054123743 hasConceptScore W2054123743C2780868878 @default.
• W2054123743 hasConceptScore W2054123743C2781069245 @default.
• W2054123743 hasConceptScore W2054123743C55493867 @default.
• W2054123743 hasConceptScore W2054123743C71924100 @default.
• W2054123743 hasConceptScore W2054123743C86803240 @default.

• next