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- W2054146811 startingPage "470" @default.
- W2054146811 abstract "Prenatal exposure to alcohol has adverse effects on offspring neuroendocrine and behavioural functions. Alcohol readily crosses the placenta, thus directly affecting developing foetal endocrine organs. In addition, alcohol-induced changes in maternal endocrine function can disrupt the normal hormonal interactions between the pregnant female and foetal systems, altering the normal hormone balance and, indirectly, affecting the development of foetal metabolic, physiological and endocrine functions. The present review focuses on the adverse effects of prenatal alcohol exposure on offspring neuroendocrine function, with particular emphasis on the hypothalamic-pituitary-adrenal (HPA) axis, a key player in the stress response. The HPA axis is highly susceptible to programming during foetal and neonatal development. Here, we review data demonstrating that alcohol exposure in utero programmes the foetal HPA axis such that HPA tone is increased throughout life. Importantly, we show that, although alterations in HPA responsiveness and regulation are robust phenomena, occurring in both male and female offspring, sexually dimorphic effects of alcohol are frequently observed. We present updated findings on possible mechanisms underlying differential effects of alcohol on male and female offspring, with special emphasis on effects at different levels of the HPA axis, and on modulatory influences of the hypothalamic-pituitary-gonadal hormones and serotonin. Finally, possible mechanisms underlying foetal programming of the HPA axis, and the long-term implications of increased exposure to endogenous glucocorticoids for offspring vulnerability to illnesses or disorders later in life are discussed." @default.
- W2054146811 created "2016-06-24" @default.
- W2054146811 creator A5037987356 @default.
- W2054146811 creator A5063143254 @default.
- W2054146811 creator A5078537040 @default.
- W2054146811 creator A5083392344 @default.
- W2054146811 date "2008-02-08" @default.
- W2054146811 modified "2023-10-14" @default.
- W2054146811 title "Prenatal Alcohol Exposure: Foetal Programming, the Hypothalamic-Pituitary-Adrenal Axis and Sex Differences in Outcome" @default.
- W2054146811 cites W12965730 @default.
- W2054146811 cites W1482114328 @default.
- W2054146811 cites W1514751206 @default.
- W2054146811 cites W1554082852 @default.
- W2054146811 cites W1570408419 @default.
- W2054146811 cites W1702455 @default.
- W2054146811 cites W1825161527 @default.
- W2054146811 cites W1838549903 @default.
- W2054146811 cites W1880891411 @default.
- W2054146811 cites W1904411025 @default.
- W2054146811 cites W1922944626 @default.
- W2054146811 cites W1951547560 @default.
- W2054146811 cites W1961990310 @default.
- W2054146811 cites W1966737898 @default.
- W2054146811 cites W1968569062 @default.
- W2054146811 cites W1969105855 @default.
- W2054146811 cites W1969388849 @default.
- W2054146811 cites W1970657660 @default.
- W2054146811 cites W1971133569 @default.
- W2054146811 cites W1971323804 @default.
- W2054146811 cites W1971362678 @default.
- W2054146811 cites W1972193475 @default.
- W2054146811 cites W1973876179 @default.
- W2054146811 cites W1974302043 @default.
- W2054146811 cites W1974607875 @default.
- W2054146811 cites W1975890243 @default.
- W2054146811 cites W1977430165 @default.
- W2054146811 cites W1977549954 @default.
- W2054146811 cites W1977977170 @default.
- W2054146811 cites W1979744299 @default.
- W2054146811 cites W1982820619 @default.
- W2054146811 cites W1983738080 @default.
- W2054146811 cites W1984902037 @default.
- W2054146811 cites W1985363054 @default.
- W2054146811 cites W1988474739 @default.
- W2054146811 cites W1990374747 @default.
- W2054146811 cites W1992533568 @default.
- W2054146811 cites W1994520348 @default.
- W2054146811 cites W1996749048 @default.
- W2054146811 cites W1998285682 @default.
- W2054146811 cites W1998521110 @default.
- W2054146811 cites W1999180056 @default.
- W2054146811 cites W2002763203 @default.
- W2054146811 cites W2003656057 @default.
- W2054146811 cites W2003895990 @default.
- W2054146811 cites W2004767882 @default.
- W2054146811 cites W2005214562 @default.
- W2054146811 cites W2005224717 @default.
- W2054146811 cites W2008328158 @default.
- W2054146811 cites W2010398761 @default.
- W2054146811 cites W2011412551 @default.
- W2054146811 cites W2012805880 @default.
- W2054146811 cites W2014570372 @default.
- W2054146811 cites W2015433651 @default.
- W2054146811 cites W2016864513 @default.
- W2054146811 cites W2019742996 @default.
- W2054146811 cites W2020017800 @default.
- W2054146811 cites W2022538398 @default.
- W2054146811 cites W2022863462 @default.
- W2054146811 cites W2024661919 @default.
- W2054146811 cites W2027062631 @default.
- W2054146811 cites W2027548555 @default.
- W2054146811 cites W2028777780 @default.
- W2054146811 cites W2030006823 @default.
- W2054146811 cites W2030063067 @default.
- W2054146811 cites W2030826355 @default.
- W2054146811 cites W2031934304 @default.
- W2054146811 cites W2032347195 @default.
- W2054146811 cites W2032629419 @default.
- W2054146811 cites W2033686024 @default.
- W2054146811 cites W2033736131 @default.
- W2054146811 cites W2035753704 @default.
- W2054146811 cites W2036227124 @default.
- W2054146811 cites W2036229386 @default.
- W2054146811 cites W2036598382 @default.
- W2054146811 cites W2036608908 @default.
- W2054146811 cites W2040909247 @default.
- W2054146811 cites W2042904751 @default.
- W2054146811 cites W2045674950 @default.
- W2054146811 cites W2045690475 @default.
- W2054146811 cites W2045988701 @default.
- W2054146811 cites W2046117790 @default.
- W2054146811 cites W2046643195 @default.
- W2054146811 cites W2048176523 @default.
- W2054146811 cites W2049878774 @default.
- W2054146811 cites W2050108249 @default.
- W2054146811 cites W2050130680 @default.
- W2054146811 cites W2050590571 @default.
- W2054146811 cites W2052603928 @default.