FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054146939> ?p ?o ?g. }

• W2054146939 endingPage "1102" @default.
• W2054146939 startingPage "1093" @default.
• W2054146939 abstract "Studies on glucocorticoid receptor (GR) action typically assess gene responses by long-term stimulation with synthetic hormones. As corticosteroids are released from adrenal glands in a circadian and high-frequency (ultradian) mode, such treatments may not provide an accurate assessment of physiological hormone action. Here we demonstrate that ultradian hormone stimulation induces cyclic GR-mediated transcriptional regulation, or gene pulsing, both in cultured cells and in animal models. Equilibrium receptor-occupancy of regulatory elements precisely tracks the ligand pulses. Nascent RNA transcripts from GR-regulated genes are released in distinct quanta, demonstrating a profound difference between the transcriptional programs induced by ultradian and constant stimulation. Gene pulsing is driven by rapid GR exchange with response elements and by GR recycling through the chaperone machinery, which promotes GR activation and reactivation in response to the ultradian hormone release, thus coupling promoter activity to the naturally occurring fluctuations in hormone levels. The GR signalling pathway has been optimized for a prompt and timely response to fluctuations in hormone levels, indicating that biologically accurate regulation of gene targets by GR requires an ultradian mode of hormone stimulation." @default.
• W2054146939 created "2016-06-24" @default.
• W2054146939 creator A5017571758 @default.
• W2054146939 creator A5020351945 @default.
• W2054146939 creator A5023528108 @default.
• W2054146939 creator A5039900996 @default.
• W2054146939 creator A5046960706 @default.
• W2054146939 creator A5061531680 @default.
• W2054146939 creator A5068072670 @default.
• W2054146939 creator A5068571537 @default.
• W2054146939 creator A5075414874 @default.
• W2054146939 creator A5082182121 @default.
• W2054146939 date "2009-08-16" @default.
• W2054146939 modified "2023-10-11" @default.
• W2054146939 title "Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription" @default.
• W2054146939 cites W1592810416 @default.
• W2054146939 cites W1650401181 @default.
• W2054146939 cites W1965144249 @default.
• W2054146939 cites W1971236504 @default.
• W2054146939 cites W1973341497 @default.
• W2054146939 cites W1982519328 @default.
• W2054146939 cites W1988666102 @default.
• W2054146939 cites W1988863726 @default.
• W2054146939 cites W1997103341 @default.
• W2054146939 cites W2004181758 @default.
• W2054146939 cites W2006369884 @default.
• W2054146939 cites W2010114834 @default.
• W2054146939 cites W2013085085 @default.
• W2054146939 cites W2028194417 @default.
• W2054146939 cites W2032093198 @default.
• W2054146939 cites W2033678048 @default.
• W2054146939 cites W2038208040 @default.
• W2054146939 cites W2053104231 @default.
• W2054146939 cites W2056406543 @default.
• W2054146939 cites W2060584995 @default.
• W2054146939 cites W2075627423 @default.
• W2054146939 cites W2077563872 @default.
• W2054146939 cites W2089731453 @default.
• W2054146939 cites W2096594220 @default.
• W2054146939 cites W2097371203 @default.
• W2054146939 cites W2103354991 @default.
• W2054146939 cites W2106278490 @default.
• W2054146939 cites W2115281458 @default.
• W2054146939 cites W2118753359 @default.
• W2054146939 cites W2125937596 @default.
• W2054146939 cites W2127849898 @default.
• W2054146939 cites W2134406847 @default.
• W2054146939 cites W2136008463 @default.
• W2054146939 cites W2137087294 @default.
• W2054146939 cites W2140504667 @default.
• W2054146939 cites W2141997480 @default.
• W2054146939 cites W2149462668 @default.
• W2054146939 cites W2166095387 @default.
• W2054146939 cites W2166776495 @default.
• W2054146939 cites W2170371611 @default.
• W2054146939 cites W2171903133 @default.
• W2054146939 cites W4229554273 @default.
• W2054146939 doi "https://doi.org/10.1038/ncb1922" @default.
• W2054146939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6711162" @default.
• W2054146939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19684579" @default.
• W2054146939 hasPublicationYear "2009" @default.
• W2054146939 type Work @default.
• W2054146939 sameAs 2054146939 @default.
• W2054146939 citedByCount "331" @default.
• W2054146939 countsByYear W20541469392012 @default.
• W2054146939 countsByYear W20541469392013 @default.
• W2054146939 countsByYear W20541469392014 @default.
• W2054146939 countsByYear W20541469392015 @default.
• W2054146939 countsByYear W20541469392016 @default.
• W2054146939 countsByYear W20541469392017 @default.
• W2054146939 countsByYear W20541469392018 @default.
• W2054146939 countsByYear W20541469392019 @default.
• W2054146939 countsByYear W20541469392020 @default.
• W2054146939 countsByYear W20541469392021 @default.
• W2054146939 countsByYear W20541469392022 @default.
• W2054146939 countsByYear W20541469392023 @default.
• W2054146939 crossrefType "journal-article" @default.
• W2054146939 hasAuthorship W2054146939A5017571758 @default.
• W2054146939 hasAuthorship W2054146939A5020351945 @default.
• W2054146939 hasAuthorship W2054146939A5023528108 @default.
• W2054146939 hasAuthorship W2054146939A5039900996 @default.
• W2054146939 hasAuthorship W2054146939A5046960706 @default.
• W2054146939 hasAuthorship W2054146939A5061531680 @default.
• W2054146939 hasAuthorship W2054146939A5068072670 @default.
• W2054146939 hasAuthorship W2054146939A5068571537 @default.
• W2054146939 hasAuthorship W2054146939A5075414874 @default.
• W2054146939 hasAuthorship W2054146939A5082182121 @default.
• W2054146939 hasBestOaLocation W20541469392 @default.
• W2054146939 hasConcept C104317684 @default.
• W2054146939 hasConcept C121446783 @default.
• W2054146939 hasConcept C126322002 @default.
• W2054146939 hasConcept C134018914 @default.
• W2054146939 hasConcept C136792703 @default.
• W2054146939 hasConcept C150194340 @default.
• W2054146939 hasConcept C165864922 @default.
• W2054146939 hasConcept C170493617 @default.
• W2054146939 hasConcept C24998067 @default.
• W2054146939 hasConcept C2780841215 @default.

• next