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• W2054147890 abstract "There is conflicting evidence on the antinociceptive effects of corticotropin-releasing factor (CRF) along the neuraxis of pain transmission and the responsible anatomical sites of CRF's action at the level of the brain, spinal cord and periphery. In an animal model of tonic pain, that is, Freunds complete adjuvant (FCA) hindpaw inflammation, we systematically investigated CRF's ability to modulate inflammatory pain at those three levels of pain transmission by algesiometry following the intracerebroventricular, intrathecal, and intraplantar application of low, systemically inactive doses of CRF. At each level, CRF elicits potent antinociceptive effects, which are dose dependent and antagonized by local, but not systemic CRF receptor antagonist α-helical CRF indicating CRF receptor specificity. Consistently, we have identified by immunohistochemistry multiple brain areas, inhibitory interneurons within the dorsal horn of the spinal cord as well as immune cells within subcutaneous tissue—but not peripheral sensory neurons—that coexpress both CRF receptors and opioid peptides. In line with these anatomical findings, local administration of CRF together with the opioid receptor antagonist naloxone dose-dependently reversed CRF's antinociceptive effects at each of these three levels of pain transmission. Therefore, local application of low, systemically inactive doses of CRF at the level of the brain, spinal cord and periphery inhibits tonic inflammatory pain most likely through an activation of CRF receptors on cells that coexpress opioid peptides which results in opioid-mediated pain inhibition. Future studies have to delineate whether endogenous CRF at these three levels contributes to the body's response to cope with the stressful stimulus pain in an opioid-mediated manner." @default.
• W2054147890 created "2016-06-24" @default.
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• W2054147890 creator A5089037190 @default.
• W2054147890 date "2007-03-21" @default.
• W2054147890 modified "2023-10-01" @default.
• W2054147890 title "Inhibition of Inflammatory Pain by CRF at Peripheral, Spinal and Supraspinal Sites: Involvement of Areas Coexpressing CRF Receptors and Opioid Peptides" @default.
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• W2054147890 cites W1883490266 @default.
• W2054147890 cites W1963627122 @default.
• W2054147890 cites W1964962825 @default.
• W2054147890 cites W1965009971 @default.
• W2054147890 cites W1967008947 @default.
• W2054147890 cites W1968172003 @default.
• W2054147890 cites W1969845682 @default.
• W2054147890 cites W1969962061 @default.
• W2054147890 cites W1970501117 @default.
• W2054147890 cites W1971232069 @default.
• W2054147890 cites W1971306310 @default.
• W2054147890 cites W1973515363 @default.
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• W2054147890 cites W2002442529 @default.
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• W2054147890 cites W2008742762 @default.
• W2054147890 cites W2008979161 @default.
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• W2054147890 cites W2010926658 @default.
• W2054147890 cites W2012416101 @default.
• W2054147890 cites W2012556825 @default.
• W2054147890 cites W2014705712 @default.
• W2054147890 cites W2019965219 @default.
• W2054147890 cites W2022263551 @default.
• W2054147890 cites W2023507956 @default.
• W2054147890 cites W2028228770 @default.
• W2054147890 cites W2028381892 @default.
• W2054147890 cites W2031098953 @default.
• W2054147890 cites W2032118892 @default.
• W2054147890 cites W2033535736 @default.
• W2054147890 cites W2034031731 @default.
• W2054147890 cites W2037974650 @default.
• W2054147890 cites W2042968286 @default.
• W2054147890 cites W2047545470 @default.
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• W2054147890 cites W2065603233 @default.
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• W2054147890 cites W2073376048 @default.
• W2054147890 cites W2073654624 @default.
• W2054147890 cites W2076144600 @default.
• W2054147890 cites W2079870520 @default.
• W2054147890 cites W2079912778 @default.
• W2054147890 cites W2083564112 @default.
• W2054147890 cites W2087454739 @default.
• W2054147890 cites W2088949216 @default.
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• W2054147890 cites W2125028680 @default.
• W2054147890 cites W2127904993 @default.
• W2054147890 cites W2137022794 @default.
• W2054147890 cites W2143629083 @default.
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• W2054147890 cites W2172190929 @default.
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• W2054147890 doi "https://doi.org/10.1038/sj.npp.1301393" @default.
• W2054147890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17375137" @default.
• W2054147890 hasPublicationYear "2007" @default.
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