FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054148524> ?p ?o ?g. }

• W2054148524 endingPage "148" @default.
• W2054148524 startingPage "145" @default.
• W2054148524 abstract "The neuroprotective effects of lithium, a mood stabilizer, against glutamate‐induced excitotoxicity in rat cortical neurons were associated with a decrease in Tyr1472 phosphorylation of the N ‐methyl‐ D ‐aspartate (NMDA) receptor NR2B subunit and a loss of receptor activity. Since this receptor tyrosine phosphorylation is mediated by the Src‐family tyrosine kinases, we investigated the effects of lithium on the Src kinase activity. Levels of phosphorylated Src kinase at Tyr416, an index of Src activation, were reduced after treatment with LiCl (1 mM) for more than 3 days. Protein levels of Src‐family kinases such as Src, Fyn, and Yes were unchanged by lithium treatment. The activities of cytosolic protein tyrosine kinase and protein phosphatase were also unchanged by lithium treatment, indicating the selectivity and the modulation. Moreover, the levels of postsynaptic densities (PSD) and SynGAP, the scaffolding proteins of the NMDA receptor complex, were unaltered by lithium. A Src kinase inhibitor, SU6656, and an NR2B antagonist, ifenprodil, partially blocked glutamate excitotoxicity. Our results suggest that lithium‐induced inactivation of Src kinase contributes to this drug‐induced NMDA receptor inhibition and neuroprotection against excitotoxicity." @default.
• W2054148524 created "2016-06-24" @default.
• W2054148524 creator A5003499703 @default.
• W2054148524 creator A5005734061 @default.
• W2054148524 creator A5065478227 @default.
• W2054148524 creator A5067999904 @default.
• W2054148524 creator A5089588271 @default.
• W2054148524 date "2003-02-21" @default.
• W2054148524 modified "2023-09-25" @default.
• W2054148524 title "Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against<i>N</i>-methyl-<scp>D</scp>-aspartate receptor-mediated excitotoxicity" @default.
• W2054148524 cites W1731473784 @default.
• W2054148524 cites W1965251357 @default.
• W2054148524 cites W1973675690 @default.
• W2054148524 cites W1983418741 @default.
• W2054148524 cites W1984057909 @default.
• W2054148524 cites W1986327387 @default.
• W2054148524 cites W1991449336 @default.
• W2054148524 cites W1991512531 @default.
• W2054148524 cites W2000837956 @default.
• W2054148524 cites W2010109108 @default.
• W2054148524 cites W2019324992 @default.
• W2054148524 cites W2027230597 @default.
• W2054148524 cites W2060792845 @default.
• W2054148524 cites W2067669919 @default.
• W2054148524 cites W2072166333 @default.
• W2054148524 cites W2072319692 @default.
• W2054148524 cites W2078246734 @default.
• W2054148524 cites W2093573816 @default.
• W2054148524 cites W2132755748 @default.
• W2054148524 cites W2146578030 @default.
• W2054148524 cites W4315557979 @default.
• W2054148524 cites W4377993708 @default.
• W2054148524 cites W2186135786 @default.
• W2054148524 doi "https://doi.org/10.1016/s0014-5793(03)00167-4" @default.
• W2054148524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12633868" @default.
• W2054148524 hasPublicationYear "2003" @default.
• W2054148524 type Work @default.
• W2054148524 sameAs 2054148524 @default.
• W2054148524 citedByCount "69" @default.
• W2054148524 countsByYear W20541485242012 @default.
• W2054148524 countsByYear W20541485242013 @default.
• W2054148524 countsByYear W20541485242014 @default.
• W2054148524 countsByYear W20541485242015 @default.
• W2054148524 countsByYear W20541485242016 @default.
• W2054148524 countsByYear W20541485242017 @default.
• W2054148524 countsByYear W20541485242018 @default.
• W2054148524 countsByYear W20541485242019 @default.
• W2054148524 countsByYear W20541485242020 @default.
• W2054148524 countsByYear W20541485242022 @default.
• W2054148524 countsByYear W20541485242023 @default.
• W2054148524 crossrefType "journal-article" @default.
• W2054148524 hasAuthorship W2054148524A5003499703 @default.
• W2054148524 hasAuthorship W2054148524A5005734061 @default.
• W2054148524 hasAuthorship W2054148524A5065478227 @default.
• W2054148524 hasAuthorship W2054148524A5067999904 @default.
• W2054148524 hasAuthorship W2054148524A5089588271 @default.
• W2054148524 hasBestOaLocation W20541485241 @default.
• W2054148524 hasConcept C108636557 @default.
• W2054148524 hasConcept C170493617 @default.
• W2054148524 hasConcept C183141693 @default.
• W2054148524 hasConcept C184235292 @default.
• W2054148524 hasConcept C185592680 @default.
• W2054148524 hasConcept C196347352 @default.
• W2054148524 hasConcept C25498285 @default.
• W2054148524 hasConcept C2779976819 @default.
• W2054148524 hasConcept C2781012912 @default.
• W2054148524 hasConcept C42362537 @default.
• W2054148524 hasConcept C55493867 @default.
• W2054148524 hasConcept C62478195 @default.
• W2054148524 hasConcept C67018056 @default.
• W2054148524 hasConcept C86803240 @default.
• W2054148524 hasConcept C95444343 @default.
• W2054148524 hasConcept C98274493 @default.
• W2054148524 hasConceptScore W2054148524C108636557 @default.
• W2054148524 hasConceptScore W2054148524C170493617 @default.
• W2054148524 hasConceptScore W2054148524C183141693 @default.
• W2054148524 hasConceptScore W2054148524C184235292 @default.
• W2054148524 hasConceptScore W2054148524C185592680 @default.
• W2054148524 hasConceptScore W2054148524C196347352 @default.
• W2054148524 hasConceptScore W2054148524C25498285 @default.
• W2054148524 hasConceptScore W2054148524C2779976819 @default.
• W2054148524 hasConceptScore W2054148524C2781012912 @default.
• W2054148524 hasConceptScore W2054148524C42362537 @default.
• W2054148524 hasConceptScore W2054148524C55493867 @default.
• W2054148524 hasConceptScore W2054148524C62478195 @default.
• W2054148524 hasConceptScore W2054148524C67018056 @default.
• W2054148524 hasConceptScore W2054148524C86803240 @default.
• W2054148524 hasConceptScore W2054148524C95444343 @default.
• W2054148524 hasConceptScore W2054148524C98274493 @default.
• W2054148524 hasIssue "1-3" @default.
• W2054148524 hasLocation W20541485241 @default.
• W2054148524 hasLocation W20541485242 @default.
• W2054148524 hasOpenAccess W2054148524 @default.
• W2054148524 hasPrimaryLocation W20541485241 @default.
• W2054148524 hasRelatedWork W1496101665 @default.
• W2054148524 hasRelatedWork W1968938192 @default.
• W2054148524 hasRelatedWork W2005305051 @default.
• W2054148524 hasRelatedWork W2047046033 @default.

• next