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- W2054148822 endingPage "1825" @default.
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- W2054148822 abstract "Abstract: The astrocytoma cell line rat C6 glioma has been used as a model system to study the mechanism of various opioid actions. Nevertheless, the type of opioid receptor(s) involved has not been established. Here we demonstrate the presence of high-affinity U69,593, endomorphin-1, morphine, and β-endorphin binding in desipramine (DMI)-treated C6 cell membranes by performing homologous and heterologous binding assays with [3H]U69,593, [3H]morphine, or 125I-β-endorphin. Naive C6 cell membranes displayed U69,593 but neither endomorphin-1, morphine, nor β-endorphin binding. Cross-linking of 125I-β-endorphin to C6 membranes gave labeled bands characteristic of opioid receptors. Moreover, RT-PCR analysis of opioid receptor expression in control and DMI-treated C6 cells indicate that both κ- and μ-opioid receptors are expressed. There does not appear to be a significant difference in the level of μ nor κ receptor expression in naive versus C6 cells treated with DMI over a 20-h period. Collectively, the data indicate that κ- and μ-opioid receptors are present in C6 glioma cells." @default.
- W2054148822 created "2016-06-24" @default.
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- W2054148822 date "2002-11-13" @default.
- W2054148822 modified "2023-10-04" @default.
- W2054148822 title "Evidence for κ- and μ-Opioid Receptor Expression in C6 Glioma Cells" @default.
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- W2054148822 doi "https://doi.org/10.1046/j.1471-4159.1998.70051819.x" @default.
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