FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054155867> ?p ?o ?g. }

• W2054155867 endingPage "493" @default.
• W2054155867 startingPage "488" @default.
• W2054155867 abstract "This prospective, open-label extension (SP702; NCT00594165) of a 6-month double-blind, randomized study investigated the long-term safety and tolerability of rotigotine transdermal system in early Parkinson's disease (PD).Patients with early-stage idiopathic PD received transdermal rotigotine for up to 6 years at optimal dose (up to 16 mg/24h). Adjunctive levodopa was allowed. Primary outcomes included adverse events (AEs) and extent of rotigotine exposure. Other outcomes included time to levodopa, incidence of dyskinesias, and efficacy using the Unified Parkinson's Disease Rating Scale (UPDRS) II+III total score.Of 217 patients entering the open-label study, 47% were still in the study upon closure; 24% withdrew because of AEs and 6% because of lack of efficacy. The median exposure to rotigotine was 1910 days (≈ 5 years, 3 months; range 1-2188 days). Most common AEs were somnolence (23% per patient-year), falls (17%), peripheral edema (14%), nausea (12%), and application site reactions (ASRs; 12%). 3% withdrew because of ASRs. 26% patients did not initiate levodopa; of those who did, fewer than half started levodopa in the first year. Dyskinesias were reported by 25% patients; the majority (83%) reported their first episode after initiating levodopa. Mean UPDRS II+III total scores remained below double-blind baseline for up to 2 years of open-label treatment.This is the longest interventional study of rotigotine conducted to date. Transdermal rotigotine was generally well tolerated for up to 6 years; AEs reported were similar to those observed in shorter studies and led to discontinuation in only 24% patients." @default.
• W2054155867 created "2016-06-24" @default.
• W2054155867 creator A5051418285 @default.
• W2054155867 creator A5068655451 @default.
• W2054155867 creator A5090106417 @default.
• W2054155867 creator A5091050492 @default.
• W2054155867 date "2012-06-01" @default.
• W2054155867 modified "2023-09-26" @default.
• W2054155867 title "Long-term safety and tolerability of rotigotine transdermal system in patients with early-stage idiopathic Parkinson’s disease: A prospective, open-label extension study" @default.
• W2054155867 cites W197066864 @default.
• W2054155867 cites W1990967797 @default.
• W2054155867 cites W1994511657 @default.
• W2054155867 cites W2011753092 @default.
• W2054155867 cites W2014583561 @default.
• W2054155867 cites W2033662966 @default.
• W2054155867 cites W2038235076 @default.
• W2054155867 cites W2070048521 @default.
• W2054155867 cites W2070453648 @default.
• W2054155867 cites W2070877964 @default.
• W2054155867 cites W2077350375 @default.
• W2054155867 cites W2087558873 @default.
• W2054155867 cites W2091683685 @default.
• W2054155867 cites W2098749010 @default.
• W2054155867 cites W2102262133 @default.
• W2054155867 cites W2120044435 @default.
• W2054155867 cites W2123909243 @default.
• W2054155867 cites W2132307715 @default.
• W2054155867 cites W2141713617 @default.
• W2054155867 cites W2169802060 @default.
• W2054155867 cites W2322912881 @default.
• W2054155867 cites W4230194219 @default.
• W2054155867 cites W4252472226 @default.
• W2054155867 doi "https://doi.org/10.1016/j.parkreldis.2012.01.008" @default.
• W2054155867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22326237" @default.
• W2054155867 hasPublicationYear "2012" @default.
• W2054155867 type Work @default.
• W2054155867 sameAs 2054155867 @default.
• W2054155867 citedByCount "47" @default.
• W2054155867 countsByYear W20541558672013 @default.
• W2054155867 countsByYear W20541558672014 @default.
• W2054155867 countsByYear W20541558672015 @default.
• W2054155867 countsByYear W20541558672016 @default.
• W2054155867 countsByYear W20541558672017 @default.
• W2054155867 countsByYear W20541558672018 @default.
• W2054155867 countsByYear W20541558672019 @default.
• W2054155867 countsByYear W20541558672020 @default.
• W2054155867 countsByYear W20541558672021 @default.
• W2054155867 countsByYear W20541558672022 @default.
• W2054155867 crossrefType "journal-article" @default.
• W2054155867 hasAuthorship W2054155867A5051418285 @default.
• W2054155867 hasAuthorship W2054155867A5068655451 @default.
• W2054155867 hasAuthorship W2054155867A5090106417 @default.
• W2054155867 hasAuthorship W2054155867A5091050492 @default.
• W2054155867 hasConcept C126322002 @default.
• W2054155867 hasConcept C141071460 @default.
• W2054155867 hasConcept C197934379 @default.
• W2054155867 hasConcept C205679159 @default.
• W2054155867 hasConcept C2775842315 @default.
• W2054155867 hasConcept C2778375690 @default.
• W2054155867 hasConcept C2778715236 @default.
• W2054155867 hasConcept C2779134260 @default.
• W2054155867 hasConcept C2779424955 @default.
• W2054155867 hasConcept C2779734285 @default.
• W2054155867 hasConcept C2780304432 @default.
• W2054155867 hasConcept C2780580376 @default.
• W2054155867 hasConcept C42219234 @default.
• W2054155867 hasConcept C71924100 @default.
• W2054155867 hasConcept C98274493 @default.
• W2054155867 hasConceptScore W2054155867C126322002 @default.
• W2054155867 hasConceptScore W2054155867C141071460 @default.
• W2054155867 hasConceptScore W2054155867C197934379 @default.
• W2054155867 hasConceptScore W2054155867C205679159 @default.
• W2054155867 hasConceptScore W2054155867C2775842315 @default.
• W2054155867 hasConceptScore W2054155867C2778375690 @default.
• W2054155867 hasConceptScore W2054155867C2778715236 @default.
• W2054155867 hasConceptScore W2054155867C2779134260 @default.
• W2054155867 hasConceptScore W2054155867C2779424955 @default.
• W2054155867 hasConceptScore W2054155867C2779734285 @default.
• W2054155867 hasConceptScore W2054155867C2780304432 @default.
• W2054155867 hasConceptScore W2054155867C2780580376 @default.
• W2054155867 hasConceptScore W2054155867C42219234 @default.
• W2054155867 hasConceptScore W2054155867C71924100 @default.
• W2054155867 hasConceptScore W2054155867C98274493 @default.
• W2054155867 hasIssue "5" @default.
• W2054155867 hasLocation W20541558671 @default.
• W2054155867 hasLocation W20541558672 @default.
• W2054155867 hasOpenAccess W2054155867 @default.
• W2054155867 hasPrimaryLocation W20541558671 @default.
• W2054155867 hasRelatedWork W1498291894 @default.
• W2054155867 hasRelatedWork W1696672465 @default.
• W2054155867 hasRelatedWork W1975304396 @default.
• W2054155867 hasRelatedWork W2011366475 @default.
• W2054155867 hasRelatedWork W2013095143 @default.
• W2054155867 hasRelatedWork W2038235076 @default.
• W2054155867 hasRelatedWork W2067529168 @default.
• W2054155867 hasRelatedWork W2227696677 @default.
• W2054155867 hasRelatedWork W2461783644 @default.
• W2054155867 hasRelatedWork W4253557999 @default.

• next