Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054156766> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2054156766 endingPage "20" @default.
- W2054156766 startingPage "15" @default.
- W2054156766 abstract "In order to prepare a liquid formulation for a weak electrolyte, micellization or complexation is often applied with the solution pH controlled to have some of the drug molecules ionized. The efficiency of the micellization is evaluated by either the micellar solubilization capacities, kappau, and kappai or the micellar partition coefficients, Ku(m) and Ki(m), for the unionized and ionized drug species. Similarly, the efficiency of complexation is evaluated by either the complex solubilization capacities, tauu and taui or the drug-ligand binding constants,Ku(1:1) and Ki(1:1). In this study, the experimental values of these descriptors were generated for seven ionizable drugs. The relationships of the logarithms of each descriptor to the logarithm of the octanol-water partition coefficient of the unionized drug (log Pu) and ionized drug species (log Pi) were evaluated. Although kappa and tau cannot be predicted, this study shows that Km and K1:1 are dependent on log P for both the unionized and ionized drug species. Thus, the total drug solubility for a weak electrolyte solubilized by micellization or complexation can be predicted at any pH." @default.
- W2054156766 created "2016-06-24" @default.
- W2054156766 creator A5005851207 @default.
- W2054156766 creator A5052887308 @default.
- W2054156766 date "2006-05-01" @default.
- W2054156766 modified "2023-09-29" @default.
- W2054156766 title "Solubilization of monovalent weak electrolytes by micellization or complexation" @default.
- W2054156766 cites W1973630175 @default.
- W2054156766 cites W1981588418 @default.
- W2054156766 cites W1988913236 @default.
- W2054156766 cites W2032655683 @default.
- W2054156766 cites W2044110570 @default.
- W2054156766 cites W2063473261 @default.
- W2054156766 cites W2065658091 @default.
- W2054156766 cites W2079261282 @default.
- W2054156766 cites W2101655202 @default.
- W2054156766 cites W2127205020 @default.
- W2054156766 cites W215025240 @default.
- W2054156766 cites W287828772 @default.
- W2054156766 doi "https://doi.org/10.1016/j.ijpharm.2006.01.039" @default.
- W2054156766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16580158" @default.
- W2054156766 hasPublicationYear "2006" @default.
- W2054156766 type Work @default.
- W2054156766 sameAs 2054156766 @default.
- W2054156766 citedByCount "14" @default.
- W2054156766 countsByYear W20541567662012 @default.
- W2054156766 countsByYear W20541567662013 @default.
- W2054156766 countsByYear W20541567662016 @default.
- W2054156766 countsByYear W20541567662018 @default.
- W2054156766 countsByYear W20541567662019 @default.
- W2054156766 crossrefType "journal-article" @default.
- W2054156766 hasAuthorship W2054156766A5005851207 @default.
- W2054156766 hasAuthorship W2054156766A5052887308 @default.
- W2054156766 hasConcept C11268172 @default.
- W2054156766 hasConcept C147789679 @default.
- W2054156766 hasConcept C155574463 @default.
- W2054156766 hasConcept C17525397 @default.
- W2054156766 hasConcept C184651966 @default.
- W2054156766 hasConcept C185592680 @default.
- W2054156766 hasConcept C192552737 @default.
- W2054156766 hasConcept C201399114 @default.
- W2054156766 hasConcept C43617362 @default.
- W2054156766 hasConcept C4863142 @default.
- W2054156766 hasConcept C55493867 @default.
- W2054156766 hasConcept C68801617 @default.
- W2054156766 hasConcept C71240020 @default.
- W2054156766 hasConceptScore W2054156766C11268172 @default.
- W2054156766 hasConceptScore W2054156766C147789679 @default.
- W2054156766 hasConceptScore W2054156766C155574463 @default.
- W2054156766 hasConceptScore W2054156766C17525397 @default.
- W2054156766 hasConceptScore W2054156766C184651966 @default.
- W2054156766 hasConceptScore W2054156766C185592680 @default.
- W2054156766 hasConceptScore W2054156766C192552737 @default.
- W2054156766 hasConceptScore W2054156766C201399114 @default.
- W2054156766 hasConceptScore W2054156766C43617362 @default.
- W2054156766 hasConceptScore W2054156766C4863142 @default.
- W2054156766 hasConceptScore W2054156766C55493867 @default.
- W2054156766 hasConceptScore W2054156766C68801617 @default.
- W2054156766 hasConceptScore W2054156766C71240020 @default.
- W2054156766 hasIssue "1" @default.
- W2054156766 hasLocation W20541567661 @default.
- W2054156766 hasLocation W20541567662 @default.
- W2054156766 hasOpenAccess W2054156766 @default.
- W2054156766 hasPrimaryLocation W20541567661 @default.
- W2054156766 hasRelatedWork W198492043 @default.
- W2054156766 hasRelatedWork W1989593392 @default.
- W2054156766 hasRelatedWork W2056554273 @default.
- W2054156766 hasRelatedWork W2161424251 @default.
- W2054156766 hasRelatedWork W2321538013 @default.
- W2054156766 hasRelatedWork W2360305448 @default.
- W2054156766 hasRelatedWork W2391982268 @default.
- W2054156766 hasRelatedWork W3024223573 @default.
- W2054156766 hasRelatedWork W4213368947 @default.
- W2054156766 hasRelatedWork W4303954709 @default.
- W2054156766 hasVolume "314" @default.
- W2054156766 isParatext "false" @default.
- W2054156766 isRetracted "false" @default.
- W2054156766 magId "2054156766" @default.
- W2054156766 workType "article" @default.