Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054165057> ?p ?o ?g. }
- W2054165057 endingPage "1530" @default.
- W2054165057 startingPage "1526" @default.
- W2054165057 abstract "Striatal dopaminergic activity is significantly correlated with various cognitive activities, mood regulation, and even metabolic homeostasis, and is modulated by the dopamine transporter (DAT). The availability of DAT could be regulated by presynaptic autoreceptors, which are G-protein coupled receptors; however, whether functional variations in the common downstream signaling molecule, G-protein, could cause individual differences in presynaptic transporter availability remains unclear. To investigate this relationship, the DAT availability in seventy-eight healthy subjects was approximated using single photon emission computed tomography (SPECT) with [(99m)Tc] TRODAT-1, a radio-labeled form of tropan derivative for the selective labeling of DAT. The C825T single nucleotide polymorphism (SNP) (rs5443) of the beta subunit of the G-protein second messenger (GNβ3) gene was genotyped, and analysis of variance showed a significant difference in striatal DAT when referenced to the entire occipital lobe among the three genotypes. Post hoc independent t tests were also performed, and showed that the striatal DAT availability of the CC genotype was higher than that of the other two genotypes. These results indicated that genetic variation in the common downstream signaling molecule of the dopamine autoreceptor could affect the functional status of the striatal dopamine system. These results together with the known role of the GNβ3 gene might provide further evidence to support the common effect of the striatal dopamine system on mood and metabolic regulation." @default.
- W2054165057 created "2016-06-24" @default.
- W2054165057 creator A5033222658 @default.
- W2054165057 creator A5043025837 @default.
- W2054165057 creator A5044896871 @default.
- W2054165057 creator A5049177021 @default.
- W2054165057 creator A5052186499 @default.
- W2054165057 creator A5052566797 @default.
- W2054165057 creator A5085455575 @default.
- W2054165057 creator A5086407741 @default.
- W2054165057 creator A5088110005 @default.
- W2054165057 creator A5088911117 @default.
- W2054165057 date "2011-06-01" @default.
- W2054165057 modified "2023-10-14" @default.
- W2054165057 title "Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study" @default.
- W2054165057 cites W1968495812 @default.
- W2054165057 cites W1972804778 @default.
- W2054165057 cites W1973592426 @default.
- W2054165057 cites W1978464376 @default.
- W2054165057 cites W1984395863 @default.
- W2054165057 cites W1990454576 @default.
- W2054165057 cites W2000436879 @default.
- W2054165057 cites W2004002137 @default.
- W2054165057 cites W2006097744 @default.
- W2054165057 cites W2014620293 @default.
- W2054165057 cites W2017263312 @default.
- W2054165057 cites W2020202045 @default.
- W2054165057 cites W2020980272 @default.
- W2054165057 cites W2021190102 @default.
- W2054165057 cites W2021449356 @default.
- W2054165057 cites W2023725307 @default.
- W2054165057 cites W2028980996 @default.
- W2054165057 cites W2029800502 @default.
- W2054165057 cites W2035078253 @default.
- W2054165057 cites W2042786251 @default.
- W2054165057 cites W2052275359 @default.
- W2054165057 cites W2054229000 @default.
- W2054165057 cites W2054432255 @default.
- W2054165057 cites W2056812151 @default.
- W2054165057 cites W2057121506 @default.
- W2054165057 cites W2064359303 @default.
- W2054165057 cites W2064559319 @default.
- W2054165057 cites W2067753833 @default.
- W2054165057 cites W2070086714 @default.
- W2054165057 cites W2073183863 @default.
- W2054165057 cites W2073948966 @default.
- W2054165057 cites W2080895738 @default.
- W2054165057 cites W2099120666 @default.
- W2054165057 cites W2099428366 @default.
- W2054165057 cites W2124384418 @default.
- W2054165057 cites W2125142132 @default.
- W2054165057 cites W2135265237 @default.
- W2054165057 cites W2153283433 @default.
- W2054165057 cites W2164125772 @default.
- W2054165057 cites W2417968103 @default.
- W2054165057 doi "https://doi.org/10.1016/j.neuroimage.2010.10.082" @default.
- W2054165057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21371559" @default.
- W2054165057 hasPublicationYear "2011" @default.
- W2054165057 type Work @default.
- W2054165057 sameAs 2054165057 @default.
- W2054165057 citedByCount "20" @default.
- W2054165057 countsByYear W20541650572012 @default.
- W2054165057 countsByYear W20541650572013 @default.
- W2054165057 countsByYear W20541650572014 @default.
- W2054165057 countsByYear W20541650572015 @default.
- W2054165057 countsByYear W20541650572016 @default.
- W2054165057 countsByYear W20541650572017 @default.
- W2054165057 countsByYear W20541650572018 @default.
- W2054165057 countsByYear W20541650572020 @default.
- W2054165057 countsByYear W20541650572022 @default.
- W2054165057 crossrefType "journal-article" @default.
- W2054165057 hasAuthorship W2054165057A5033222658 @default.
- W2054165057 hasAuthorship W2054165057A5043025837 @default.
- W2054165057 hasAuthorship W2054165057A5044896871 @default.
- W2054165057 hasAuthorship W2054165057A5049177021 @default.
- W2054165057 hasAuthorship W2054165057A5052186499 @default.
- W2054165057 hasAuthorship W2054165057A5052566797 @default.
- W2054165057 hasAuthorship W2054165057A5085455575 @default.
- W2054165057 hasAuthorship W2054165057A5086407741 @default.
- W2054165057 hasAuthorship W2054165057A5088110005 @default.
- W2054165057 hasAuthorship W2054165057A5088911117 @default.
- W2054165057 hasConcept C104317684 @default.
- W2054165057 hasConcept C120069818 @default.
- W2054165057 hasConcept C126322002 @default.
- W2054165057 hasConcept C134018914 @default.
- W2054165057 hasConcept C135763542 @default.
- W2054165057 hasConcept C137183658 @default.
- W2054165057 hasConcept C139275648 @default.
- W2054165057 hasConcept C153209595 @default.
- W2054165057 hasConcept C15744967 @default.
- W2054165057 hasConcept C169760540 @default.
- W2054165057 hasConcept C170493617 @default.
- W2054165057 hasConcept C2775864247 @default.
- W2054165057 hasConcept C2776755682 @default.
- W2054165057 hasConcept C513476851 @default.
- W2054165057 hasConcept C54355233 @default.
- W2054165057 hasConcept C71924100 @default.
- W2054165057 hasConcept C8439214 @default.